Pulmonary fibrosis is a debilitating and life-limiting lung condition in which the damage-
response mechanisms of mixed-population cells within the lungs go awry. The tissue …

Complications of the liver are amongst the world's worst diseases. Liver fibrosis is the first
stage of liver problems, while cirrhosis is the last stage, which can lead to death. The …

Caffeine elicits protective effects against liver diseases, such as NASH; however, its
mechanism of action involving the pyrin domain-containing-3 (NLRP3) inflammasome …

Non-alcoholic steatohepatitis (NASH) is a global public health concern that may progress
into fibrosis, cirrhosis, and liver cancer, with limited curative treatment options. While the …

Background Epidemiological evidence has shown an association between coffee
consumption and reduced risk for chronic liver diseases, including metabolic-dysfunction …

Mitochondrial dysfunction is one of the key mechanisms for developing chronic kidney
disease (CKD). Hyperoxaluria and nephrolithiasis are also associated with mitochondrial …

Introduction and objectives Administration of carbon tetrachloride (CCl 4), along with an
hepatopathogenic diet, is widely employed as a chemical inducer to replicate human …

Background and aims In metabolic (dysfunction)-associated fatty liver disease (MAFLD),
activation of inflammatory processes marks the transition of simple steatosis to …

The antioxidant effect of caffeine, associated with its ability to upregulate the nuclear factor-
E2-related factor-2 (Nrf2)-signaling pathway, was explored as a possible mechanism for the …

Liver fibrosis is an intrahepatic chronic damage repair response caused by various reasons
such as alcoholic liver, fatty liver, viral hepatitis, autoimmune diseases, etc., and is closely …