Mucopolysaccharidosis (MPS) type I and II are two closely related lysosomal storage
diseases associated with disrupted glycosaminoglycan catabolism. In MPS II, the first step of …

Norbin (Neurochondrin, NCDN) is a highly conserved 79 kDa adaptor protein that was first
identified more than a quarter of a century ago as a gene up-regulated in rat hippocampus …

Mucopolysaccharidosis type II (MPS II) results from the dysfunction of a lysosomal enzyme,
iduronate-2-sulfatase (IDS). Dysfunction of IDS triggers the lysosomal accumulation of its …

The major function of the lysosome is to degrade unwanted materials such as lipids,
proteins, and nucleic acids; therefore, deficits of the lysosomal system can result in improper …

Gut-microbiome-derived metabolites, such as 4-Ethylphenol [4EP], have been shown to
modulate neurological health and function. Although the source of such metabolites is …

Lysosomal storage diseases (LSDs) are a group of about 50 inborn errors of metabolism
characterized by the lysosomal accumulation of partially or non-degraded molecules due to …

Abstract The Lysosomal Storage disease known as Mucopolysaccharidosis type II, is
caused by mutations affecting the iduronate-2-sulfatase required for heparan and dermatan …

Background Mucopolysaccharidosis type II (MPS II), also known as Hunter syndrome, is a
rare X-linked recessive disease caused by a deficiency of the lysosomal enzyme iduronate …

The purpose of this development research is to produce teaching materials in the form of
problem-based learning-based bioinformatics e-modules for biochemistry courses that meet …