Approximately 1.6 million new cases of lung cancer are diagnosed each year throughout the
world. In many countries, the mortality related to lung cancer continues to rise. The outcomes …

Tyrosine kinases are important cellular signaling proteins that have a variety of biological
activities including cell proliferation and migration. Multiple kinases are involved in …

Abstract Background Receptor tyrosine kinases (RTKs) are signaling enzymes responsible
for the transfer of Adenosine triphosphate (ATP) γ-phosphate to the tyrosine residues …

Oncolytic viruses (OVs) are genetically modified or naturally occurring viruses, which
preferentially replicate in and kill cancer cells while sparing healthy cells, and induce anti …

Purpose: To evaluate if diastolic blood pressure (dBP)≥ 90 mm Hg during axitinib treatment
is a marker of efficacy. Experimental Design: The relationship between dBP≥ 90 mm Hg …

Axitinib is a potent and selective inhibitor of vascular endothelial growth factor receptors 1, 2,
and 3, approved for second‐line therapy for advanced renal cell carcinoma (RCC). Axitinib …

Axitinib is a potent and selective second-generation inhibitor of vascular endothelial growth
factor receptors 1, 2, and 3 that is approved in the US and several other countries for …

The vascular endothelial growth factor (VEGF) signaling pathway appears to be the
dominant pathway involved in tumor angiogenesis, providing a rationale for targeting the …

Tumorigenesis is a complex multistep process involving not only genetic and epigenetic
changes in the tumor cell but also selective supportive conditions of the deregulated tumor …

Aims To investigate the overall incidence and risk of hypertension in cancer patients who
receive axitinib and compare the differences in incidences between axitinib and the other …