The role of voltage-gated sodium channels in pain signaling
Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …
Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities
Pain medication plays an important role in the treatment of acute and chronic pain
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …
Multisystem involvement in post‐acute sequelae of coronavirus disease 19
Objective The purpose of this study was to describe cerebrovascular, neuropathic, and
autonomic features of post‐acute sequelae of coronavirus disease 2019 ((COVID‐19) …
autonomic features of post‐acute sequelae of coronavirus disease 2019 ((COVID‐19) …
Challenges of neuropathic pain: focus on diabetic neuropathy
DC Rosenberger, V Blechschmidt… - Journal of Neural …, 2020 - Springer
Neuropathic pain is a frequent condition caused by a lesion or disease of the central or
peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain …
peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain …
Painful and non-painful diabetic neuropathy, diagnostic challenges and implications for future management
TS Jensen, P Karlsson, SS Gylfadottir, ST Andersen… - Brain, 2021 - academic.oup.com
Peripheral neuropathy is one of the most common complications of both type 1 and type 2
diabetes. Up to half of patients with diabetes develop neuropathy during the course of their …
diabetes. Up to half of patients with diabetes develop neuropathy during the course of their …
Neuropathic pain: principles of diagnosis and treatment
Neuropathic pain is caused by disease or injury of the nervous system and includes various
chronic conditions that, together, affect up to 8% of the population. A substantial body of …
chronic conditions that, together, affect up to 8% of the population. A substantial body of …
Studying human nociceptors: from fundamentals to clinic
Chronic pain affects one in five of the general population and is the third most important
cause of disability-adjusted life-years globally. Unfortunately, treatment remains inadequate …
cause of disability-adjusted life-years globally. Unfortunately, treatment remains inadequate …
Neuropathic pain: mechanisms and their clinical implications
Neuropathic pain can develop after nerve injury, when deleterious changes occur in injured
neurons and along nociceptive and descending modulatory pathways in the central nervous …
neurons and along nociceptive and descending modulatory pathways in the central nervous …
The diagnostic challenge of small fibre neuropathy: clinical presentations, evaluations, and causes
Small fibre neuropathies are a heterogeneous group of disorders affecting thinly myelinated
Aδ-fibres and unmyelinated C-fibres. Although multiple causes of small nerve fibre …
Aδ-fibres and unmyelinated C-fibres. Although multiple causes of small nerve fibre …
Corneal nerves in health and disease
MA Al-Aqaba, VK Dhillon, I Mohammed… - Progress in retinal and …, 2019 - Elsevier
The cornea is the most sensitive structure in the human body. Corneal nerves adapt to
maintain transparency and contribute to corneal health by mediating tear secretion and …
maintain transparency and contribute to corneal health by mediating tear secretion and …