TLR4-targeting therapeutics: structural basis and computer-aided drug discovery approaches
The integration of computational techniques into drug development has led to a substantial
increase in the knowledge of structural, chemical, and biological data. These techniques are …
increase in the knowledge of structural, chemical, and biological data. These techniques are …
Interaction of opioids with TLR4—mechanisms and ramifications
Simple Summary Recent evidence indicates that opioids can be active at a receptor that is
abundantly expressed on innate immune cells as well as cancer cells: the receptor is termed …
abundantly expressed on innate immune cells as well as cancer cells: the receptor is termed …
Recent advances on Toll-like receptor 4 modulation: new therapeutic perspectives
L Zaffaroni, F Peri - Future medicinal chemistry, 2018 - Future Science
Activation or inhibition of TLR4 by small molecules will provide in the next few years a new
generation of therapeutics. TLR4 stimulation (agonism) by high-affinity ligands mimicking …
generation of therapeutics. TLR4 stimulation (agonism) by high-affinity ligands mimicking …
[HTML][HTML] Toll-like receptor 4 signaling and drug addiction
The emphasis of neuronal alterations and adaptations have long been the main focus of the
studies of the mechanistic underpinnings of drug addiction. Recent studies have begun to …
studies of the mechanistic underpinnings of drug addiction. Recent studies have begun to …
[HTML][HTML] Structure-based virtual screening, molecular docking, and molecular dynamics simulation of VEGF inhibitors for the clinical treatment of ovarian cancer
Vascular endothelial growth factor (VEGF) and its receptor play an important role both in
physiologic and pathologic angiogenesis, which is identified in ovarian cancer progression …
physiologic and pathologic angiogenesis, which is identified in ovarian cancer progression …
Linear and rationally designed stapled peptides abrogate TLR4 pathway and relieve inflammatory symptoms in rheumatoid arthritis rat model
A mounting evidence exists for the despicable role of the aberrant immune response in the
pathogenesis of rheumatoid arthritis (RA), where toll-like receptor 4 (TLR4) can activate …
pathogenesis of rheumatoid arthritis (RA), where toll-like receptor 4 (TLR4) can activate …
Lung cancer cells release high mobility group box 1 and promote the formation of neutrophil extracellular traps
J Zhou, Y Yang, T Gan, Y Li, F Hu… - Oncology …, 2019 - spandidos-publications.com
Lung cancer is the leading cause of cancer‑associated mortality. Tumor‑associated
neutrophils represent a large portion of inflammatory cells within the lung tumor …
neutrophils represent a large portion of inflammatory cells within the lung tumor …
The potential interplay between opioid and the toll-like receptor 4 (TLR-4)
N Zare, M Pourhadi, G Vaseghi… - …, 2023 - Taylor & Francis
Context Opioids are available for the management of severe and chronic pain. However,
long-term use of high-dose opioids could lead to physiologic tolerance, hyperalgesia …
long-term use of high-dose opioids could lead to physiologic tolerance, hyperalgesia …
Structure-based virtual screening, molecular docking, molecular dynamics simulation and pharmacokinetic modelling of cyclooxygenase-2 (COX-2) inhibitor for the …
Colorectal cancer is the third most frequent cause of cancer worldwide and is more
prevalent in older individuals of all ages. The recent statistics from World Health …
prevalent in older individuals of all ages. The recent statistics from World Health …
Alum and a TLR7 agonist combined with built-in TLR4 and 5 agonists synergistically enhance immune responses against HPV RG1 epitope
M Mashhadi Abolghasem Shirazi, SM Sadat… - Scientific Reports, 2023 - nature.com
To relieve the limitations of the human papillomavirus (HPV) vaccines based on L1 capsid
protein, vaccine formulations based on RG1 epitope of HPV L2 using various built-in …
protein, vaccine formulations based on RG1 epitope of HPV L2 using various built-in …