For the average biologist, hands-on literature mining currently means a keyword search in
PubMed. However, methods for extracting biomedical facts from the scientific literature have …

Cyclins regulate the cell cycle by binding to and activating cyclin-dependent kinases (Cdks).
Phosphorylation of specific targets by cyclin–Cdk complexes sets in motion different …

The cyclin dependent kinase Cdk1 controls the cell cycle, which is best understood in the
model organism S. cerevisiae. Research performed during the past decade has significantly …

14-3-3 proteins play critical roles in the regulation of cell fate through phospho-dependent
binding to a large number of intracellular proteins that are targeted by various classes of …

Cdk specificity is determined by the intrinsic selectivity of the active site and by substrate
docking sites on the cyclin subunit. There is a long-standing debate about the relative …

Studies of the processes leading to the construction of a bud and its separation from the
mother cell in Saccharomyces cerevisiae have provided foundational paradigms for the …

At the onset of M phase, the activity of somatic Wee1 (Wee1A), the inhibitory kinase for cyclin-
dependent kinase (CDK), is down-regulated primarily through proteasome-dependent …

Summary Saccharomyces WEE1 (Swe1), the only" true" tyrosine kinase in budding yeast, is
an Hsp90 client protein. Here we show that Swe1 Wee1 phosphorylates a conserved …

Control of cell cycle progression by stress‐activated protein kinases (SAPKs) is essential for
cell adaptation to extracellular stimuli. Exposure of yeast to osmostress leads to activation of …

Protein kinases are important regulators of intracellular signal transduction pathways and
play critical roles in diverse cellular functions. Once a protein kinase is activated, its activity …