Over the past several decades, the incidence of early-onset colorectal cancer (EOCRC; in
patients< 50 years old) has increased at an alarming rate. Although robust and scientifically …

Myo-inositol (myo-Ins) and D-chiro-inositol (D-chiro-Ins) are natural compounds involved in
many biological pathways. Since the discovery of their involvement in endocrine signal …

Manipulating the tumor immune contexture towards a more active state can result in better
therapeutic outcomes. Here we describe an easily accessible bacterial biomineralization …

Aberrant coagulation and thrombosis are associated with severe COVID-19 post-SARS-CoV-
2 infection, yet the underlying mechanism remains obscure. Here we show that serum levels …

Polysaccharides extracted from Dendrobium officinale have various physiological effects. In
this study, we used D-galactose-induced senescent mice as an animal model to investigate …

Buccal mucosal membrane offers an attractive drug-delivery route to enhance both systemic
and local therapy. This review discusses the benefits and drawbacks of buccal drug delivery …

Solid lipid nanoparticles (SLNs) are being extensively exploited as topical ocular carrier
systems to enhance the bioavailability of drugs. This study investigated the prospects of drug …

Microglia is a heterogeneous population that mediates neuroinflammation in the central
nervous system (CNS) and plays a crucial role in developing neuropathic pain. FKBP5 …

The pharmacological actions of benzylisoquinoline alkaloids are quite substantial, and have
recently attracted much attention. One of the principle benzylisoquinoline alkaloids has been …

Dendrobium officinale polysaccharide (DOP) has received an increasing amount of attention
as it could alleviate AD-related cognitive impairment via the regulation of microglial …