One of the central regulators of cellular and organismal metabolism in eukaryotes is AMP-
activated protein kinase (AMPK), which is activated when intracellular ATP production …

The AMP‐activated serine/threonine protein kinase (AMPK) is a sensor of cellular energy
status found in all eukaryotes that is activated under conditions of low intracellular ATP …

AMPK is a highly conserved sensor of cellular energy status that is activated under
conditions of low intracellular ATP. AMPK responds to energy stress by suppressing cell …

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is an enigmatic condition
characterized by exacerbation of symptoms after exertion (post-exertional malaise or …

A controlled regulation of mitochondrial mass through either the production (biogenesis) or
the degradation (mitochondrial quality control) of the organelle represents a crucial step for …

Dictyostelium discoideum offers unique advantages for studying fundamental cellular
processes, host–pathogen interactions as well as the molecular causes of human diseases …

Macropinocytosis is a conserved endocytic process used by Dictyostelium amoebae for
feeding on liquid medium. To further Dictyostelium as a model for macropinocytosis, we …

The yeast Saccharomyces cerevisiae employs different conserved signaling pathways to
adapt to altered availability of nutrient and energy sources. Crosstalk between the pathways …

Werner syndrome (WS) is a premature aging disorder caused by mutations in a RecQ-like
DNA helicase. Mice lacking the helicase domain of the WRN homologue exhibit many …

In combination with studies of post-mortem Parkinson's disease (PD) brains,
pharmacological and genetic models of PD have suggested that two fundamental interacting …