Short telomeres confer risk of degenerative diseases. Chronic psychological stress can lead
to disease through many pathways, and research from in vitro studies to human longitudinal …

Significance: Social and demographic changes have led to an increased prevalence of
loneliness and social isolation in modern society. Recent Advances: Population-based …

Background Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis
in over 5% of the parenchyma in the absence of excessive alcohol consumption. It is more …

Loneliness and social isolation are common sources of chronic stress in modern society.
Epidemiological studies have demonstrated that loneliness and social isolation increase …

Background Major depressive disorder (MDD) is linked to higher cardio-metabolic
comorbidity that may in part be due to the low-grade inflammation and poorer metabolic …

Accumulating data highlight the contribution of brain mitochondria and bioenergetics to
psychiatric disorders and stress-related pathologies. Although anxiety has not received …

Parkinson's disease (PD) is defined as a chronic neurodegenerative disorder which is
diagnosed mostly by its clinical manifestations. Reactive oxygen species (ROS) are …

Age is associated with increased risk for several disorders including dementias,
cardiovascular disease, atherosclerosis, obesity, and diabetes. Age is also associated with …

Background Childhood trauma (CT) is a risk factor for depressive and anxiety disorders.
Although dysregulated biological stress systems may underlie the enduring effect of CT, the …

Major depressive disorder (MDD) is a multifactorial neuropsychiatric disorder. Chronic
administration of corticosterone (CORT) to rodents is used to mimic the stress associated …