Cytokines and chemokines involved in osteoarthritis pathogenesis

V Molnar, V Matišić, I Kodvanj, R Bjelica… - International journal of …, 2021 - mdpi.com
Osteoarthritis is a common cause of disability worldwide. Although commonly referred to as
a disease of the joint cartilage, osteoarthritis affects all joint tissues equally. The …

Knee osteoarthritis: epidemiology, pathogenesis, and mesenchymal stem cells: what else is new? An update

R Giorgino, D Albano, S Fusco, GM Peretti… - International journal of …, 2023 - mdpi.com
Osteoarthritis (OA) is a chronic disease and the most common orthopedic disorder. A vast
majority of the social OA burden is related to hips and knees. The prevalence of knee OA …

The roles of matrix metalloproteinases and their inhibitors in human diseases

GA Cabral-Pacheco, I Garza-Veloz… - International journal of …, 2020 - mdpi.com
Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM)
remodeling endopeptidases that have the capacity to degrade almost every component of …

The role of matrix metalloproteinases (MMP-8, MMP-9, MMP-13) in periodontal and peri-implant pathological processes

I Luchian, A Goriuc, D Sandu, M Covasa - International Journal of …, 2022 - mdpi.com
Severe periodontitis, a destructive inflammatory disease of the supporting tissues of the
teeth, ranks sixth in terms of global spread, affecting about 11% of the population …

Overview of MMP-13 as a promising target for the treatment of osteoarthritis

Q Hu, M Ecker - International journal of molecular sciences, 2021 - mdpi.com
Osteoarthritis (OA) is a common degenerative disease characterized by the destruction of
articular cartilage and chronic inflammation of surrounding tissues. Matrix metalloproteinase …

Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions

Y Cho, S Jeong, H Kim, D Kang, J Lee… - … & molecular medicine, 2021 - nature.com
Osteoarthritis (OA) is the most common form of arthritis. It is characterized by progressive
destruction of articular cartilage and the development of chronic pain and constitutes a …

Genistein: A review on its anti-inflammatory properties

YX Goh, J Jalil, KW Lam, K Husain… - Frontiers in …, 2022 - frontiersin.org
Nowadays, non-resolving inflammation is becoming a major trigger in various diseases as it
plays a significant role in the pathogenesis of atherosclerosis, asthma, cancer, obesity …

The development of disease-modifying therapies for osteoarthritis (DMOADs): the evidence to date

WM Oo, C Little, V Duong, DJ Hunter - Drug Design, Development …, 2021 - Taylor & Francis
Osteoarthritis (OA) is a complex heterogeneous articular disease with multiple joint tissue
involvement of varying severity and no regulatory-agency-approved disease-modifying …

Injectable drug delivery systems for osteoarthritis and rheumatoid arthritis

MC Bruno, MC Cristiano, C Celia, N d'Avanzo… - ACS …, 2022 - ACS Publications
Joint diseases are one of the most common causes of morbidity and disability worldwide.
The main diseases that affect joint cartilage are osteoarthritis and rheumatoid arthritis, which …

Cartilage calcification in osteoarthritis: mechanisms and clinical relevance

I Bernabei, A So, N Busso, S Nasi - Nature Reviews Rheumatology, 2023 - nature.com
Pathological calcification of cartilage is a hallmark of osteoarthritis (OA). Calcification can be
observed both at the cartilage surface and in its deeper layers. The formation of calcium …