The kainic acid model of temporal lobe epilepsy has greatly contributed to the
understanding of the molecular, cellular and pharmacological mechanisms underlying …

Understanding the pathophysiogenesis of temporal lobe epilepsy (TLE) largely rests on the
use of models of status epilepticus (SE), as in the case of the pilocarpine model. The main …

We investigated the activation of the IL-1β system and markers of adaptive immunity in rat
brain during epileptogenesis using models of temporal lobe epilepsy (TLE). The same …

In order to understand the pathophysiology of temporal lobe epilepsy (TLE), and thus to
develop new pharmacological treatments, in vivo animal models that present features …

Systemic administration of pilocarpine and kainic acid (KA) has been extensively used to
model temporal lobe epilepsy in rats. Here the regional distribution of selectively vulnerable …

Understanding seizure formation and spread remains a critical goal of epilepsy research.
We used fast in vivo two-photon calcium imaging in male mouse neocortex to reconstruct …

The pilocarpine animal model of status epilepticus is a well-established, clinically
translatable model that satisfies all of the criteria essential for an animal model of status …

The systemic administration of a potent muscarinic agonist pilocarpine in rats promotes
sequential behavioral and electrographic changes that can be divided into 3 distinct …

Systemic administration of pilocarpine in rats can result in a chronic behavioral state that is
similar to human temporal lobe epilepsy. The pilocarpine model of epilepsy is widely used …

Ion channelopathy plays an important role in human epilepsy with a genetic cause and has
been hypothesized to occur in epilepsy after acquired insults to the CNS as well. Acquired …