Successful pregnancy requires the maternal immune system to tolerate the semi-allogeneic
embryo. A good trophoblast function is also essential for successful embryo implantation …

Chemokines, and their receptors play a crucial role in the pathophysiology of cardiovascular
diseases (CVD). Chemokines classically mediate their effects by binding to G-protein …

Angiogenesis is the process by which new vessels form from existing vascular networks.
Human umbilical vein endothelial cells (HUVECs) may contribute to the study of vascular …

Delphinidin is a member of the anthocyanidin family and is a natural pigment in red
cabbage, berries, sweet potatoes and grapes. It possesses nutraceutical properties against …

The survival of allogeneic fetuses during pregnancy is a rather paradoxical phenomenon
with a complex mechanism. Chemokine ligand12 (CXCL12) and its receptors CXC …

Background Different from other malignant gynecologic tumors, gestational trophoblastic
neoplasms (GTNs) exhibit an exceptionally high cure rate primarily through …

Under physiological conditions, CXCL12 modulates cell proliferation, survival,
angiogenesis, and migration mainly through CXCR4. Interestingly, the newly discovered …

Metastasis is the main cause of death in cancer patients; there is currently no effective
treatment for cancer metastasis. This is primarily due to our insufficient understanding of the …

Preeclampsia is a pregnancy disorder with sudden onset of maternal hypertension and
proteinuria, which is characterized by defective cytotrophoblast invasion, increased …

The chemokine CXCL12 and its receptor CXCR4 are important signaling components
required for human blastocyst implantation and the progression of pregnancy. Growing …