Cancer cells require a massive supply of nutrients, including sugars and amino acids—the
upregulation of transporters for each nutrient contributes to meet the demand. Distinct from …

Amino acid transporters (AATs) are membrane-bound transport proteins that mediate
transfer of amino acids into and out of cells or cellular organelles. AATs have diverse …

The L-type amino acid transporter 1 (LAT1 or SLC7A5) transports large neutral amino acids
across the membrane and is crucial for brain drug delivery and tumor growth. LAT1 forms a …

Within the growing field of amino acid metabolism, tryptophan (Trp) catabolism is an area of
increasing interest. Trp is essential for protein synthesis, and its metabolism gives rise to …

Abstract α‐Methyl‐l‐tyrosine (AMT) has a high affinity for the cancer‐specific l‐type amino
acid transporter 1 (LAT1). Therefore, we established an anti‐cancer therapy, with 211At …

L-type amino acid transporters (LATs) mainly assist the uptake of neutral amino acids into
cells. Four LATs (LAT1, LAT2, LAT3 and LAT4) have so far been identified. LAT1 (SLC7A5) …

L-type amino acid transporter 1 (LAT1) is known as a cancer-type amino acid transporter. In
cancer cells, LAT1 is responsible for the cellular uptake of many essential amino acids …

Phenylalanine derivatives, which target tumors especially through L-type amino acid
transporter-1 (LAT1), have elicited considerable attention. In this study, we evaluated the …

Introduction: The ancient and ubiquitous monoamine signalling molecules serotonin,
dopamine, norepinephrine, and epinephrine are involved in multiple physiological functions …

Purpose The purpose of this study was to evaluate the usefulness of L-4-borono-2-18 F-
fluoro-phenylalanine (18 F-FBPA) as a tumor-specific probe, in comparison to 18 F-FDG and …