Low back pain is a highly prevalent, chronic, and costly medical condition predominantly
triggered by intervertebral disc degeneration (IDD). IDD is often caused by structural and …

Intervertebral disc degeneration (IDD) is a common degenerative disease of the
musculoskeletal system that develops with age. It is regarded as the main cause of chronic …

Melatonin's therapeutic potential is grossly underestimated because its functional roles are
diverse and its mechanism (s) of action are complex and varied. Melatonin produces cellular …

Low back pain (LBP) represents a frequent and debilitating condition affecting a large part of
the global population and posing a worldwide health and economic burden. The major …

Melatonin is reportedly associated with intervertebral disc degeneration (IDD). Endplate
cartilage is vitally important to intervertebral discs in physiological and pathological …

Pinealectomy in vertebrates accelerated intervertebral disk degeneration (IDD). However,
the potential mechanisms, particularly melatonin's role, are still to be clarified. In this study …

The objective of this paper was to analyze the data supporting the possible role of melatonin
on bone metabolism and its repercussion in the etiology and treatment of bone pathologies …

Intervertebral disc (IVD) degeneration (IDD) is a common disorder that affects the spine and
is a major cause of lower back pain (LBP). The extracellular matrix (ECM) is the structural …

Low back pain (LBP) is one of the most common painful conditions that lead to work
absenteeism, medical visits, and hospitalization. The majority of cases showing signs of LBP …

Study Design. Lower lumbar vertebral endplates from young and old sand rats were
assessed in an Institutional Animal Care and Use Committee approved study for …