Until relatively recently, DNA primases were viewed simply as a class of proteins that
synthesize short RNA primers requisite for the initiation of DNA replication. However, recent …

The DNA-directed primase-polymerase PrimPol of the archaeo-eukaryotic primase
superfamily represents an ancient solution to the many problems faced during genome …

Archaea, the third domain of life, are interesting organisms to study from the aspects of
molecular and evolutionary biology. Archaeal cells have a unicellular ultrastructure without a …

In Archaea, the proteins involved in the genetic information processing pathways, including
DNA replication, transcription, and translation, share strong similarities with those of …

The precise and timely duplication of the genome is essential for cellular life. It is achieved
by DNA replication, a complex process that is conserved among the three domains of life …

DNA priming and unwinding activities are coupled within bacterial primosome complexes to
initiate synthesis on the lagging strand during DNA replication. Archaeal organisms contain …

The accurate duplication and transmission of genetic information are essential and crucially
important for living organisms. The molecular mechanism of DNA replication has been one …

DNA polymerases from archaea coordinate both replication and repair activities under
extreme conditions. Traditional DNA polymerase families B and Y are represented, but an …

One of the greatest achievements in the life sciences in the 20th century was the recognition
of three forms, or domains, of cellular life, ie, Bacteria, Archaea, and Eukarya, in the three …

DNA replication is a complex process that involves an organism's ability to faithfully replicate
and maintain its genomic code. One of the initial stages of DNA replication is the separation …