Frontiers of chaotic advection

H Aref, JR Blake, M Budišić, SSS Cardoso… - Reviews of Modern …, 2017 - APS
This work reviews the present position of and surveys future perspectives in the physics of
chaotic advection: the field that emerged three decades ago at the intersection of fluid …

The pathophysiology of bronchiectasis

PT King - International journal of chronic obstructive pulmonary …, 2009 - Taylor & Francis
Bronchiectasis is defined by permanent and abnormal widening of the bronchi. This process
occurs in the context of chronic airway infection and inflammation. It is usually diagnosed …

CCDC39 is required for assembly of inner dynein arms and the dynein regulatory complex and for normal ciliary motility in humans and dogs

AC Merveille, EE Davis, A Becker-Heck, M Legendre… - Nature …, 2011 - nature.com
Primary ciliary dyskinesia (PCD) is an inherited disorder characterized by recurrent
infections of the upper and lower respiratory tract, reduced fertility in males and situs …

The dynein regulatory complex is the nexin link and a major regulatory node in cilia and flagella

T Heuser, M Raytchev, J Krell, ME Porter… - Journal of Cell …, 2009 - rupress.org
Cilia and flagella are highly conserved microtubule (MT)-based organelles with motile and
sensory functions, and ciliary defects have been linked to several human diseases. The 9+ 2 …

Mutations in axonemal dynein assembly factor DNAAF3 cause primary ciliary dyskinesia

HM Mitchison, M Schmidts, NT Loges, J Freshour… - Nature …, 2012 - nature.com
Primary ciliary dyskinesia most often arises from loss of the dynein motors that power ciliary
beating. Here we show that DNAAF3 (also known as PF22), a previously uncharacterized …

The nexin-dynein regulatory complex subunit DRC1 is essential for motile cilia function in algae and humans

M Wirschell, H Olbrich, C Werner, D Tritschler… - Nature …, 2013 - nature.com
Primary ciliary dyskinesia (PCD) is characterized by dysfunction of respiratory cilia and
sperm flagella and random determination of visceral asymmetry. Here, we identify the DRC1 …

Mechanisms of otoconia and otolith development

YW Lundberg, Y Xu, KD Thiessen… - Developmental …, 2015 - Wiley Online Library
Background: Otoconia are bio‐crystals that couple mechanic forces to the sensory hair cells
in the utricle and saccule, a process essential for us to sense linear acceleration and gravity …

Ciliary motility: regulation of axonemal dynein motors

R Viswanadha, WS Sale… - Cold Spring Harbor …, 2017 - cshperspectives.cshlp.org
Ciliary motility is crucial for the development and health of many organisms. Motility depends
on the coordinated activity of multiple dynein motors arranged in a precise pattern on the …

CEP41 is mutated in Joubert syndrome and is required for tubulin glutamylation at the cilium

JE Lee, JL Silhavy, MS Zaki, J Schroth, SL Bielas… - Nature …, 2012 - nature.com
Tubulin glutamylation is a post-translational modification that occurs predominantly in the
ciliary axoneme and has been suggested to be important for ciliary function,. However, its …

GRK2: multiple roles beyond G protein-coupled receptor desensitization

T Evron, TL Daigle, MG Caron - Trends in pharmacological sciences, 2012 - cell.com
G protein-coupled receptor kinases (GRKs) regulate numerous G protein-coupled receptors
(GPCRs) by phosphorylating the intracellular domain of the active receptor, resulting in …