Frontiers of chaotic advection
This work reviews the present position of and surveys future perspectives in the physics of
chaotic advection: the field that emerged three decades ago at the intersection of fluid …
chaotic advection: the field that emerged three decades ago at the intersection of fluid …
The pathophysiology of bronchiectasis
PT King - International journal of chronic obstructive pulmonary …, 2009 - Taylor & Francis
Bronchiectasis is defined by permanent and abnormal widening of the bronchi. This process
occurs in the context of chronic airway infection and inflammation. It is usually diagnosed …
occurs in the context of chronic airway infection and inflammation. It is usually diagnosed …
CCDC39 is required for assembly of inner dynein arms and the dynein regulatory complex and for normal ciliary motility in humans and dogs
Primary ciliary dyskinesia (PCD) is an inherited disorder characterized by recurrent
infections of the upper and lower respiratory tract, reduced fertility in males and situs …
infections of the upper and lower respiratory tract, reduced fertility in males and situs …
The dynein regulatory complex is the nexin link and a major regulatory node in cilia and flagella
T Heuser, M Raytchev, J Krell, ME Porter… - Journal of Cell …, 2009 - rupress.org
Cilia and flagella are highly conserved microtubule (MT)-based organelles with motile and
sensory functions, and ciliary defects have been linked to several human diseases. The 9+ 2 …
sensory functions, and ciliary defects have been linked to several human diseases. The 9+ 2 …
Mutations in axonemal dynein assembly factor DNAAF3 cause primary ciliary dyskinesia
HM Mitchison, M Schmidts, NT Loges, J Freshour… - Nature …, 2012 - nature.com
Primary ciliary dyskinesia most often arises from loss of the dynein motors that power ciliary
beating. Here we show that DNAAF3 (also known as PF22), a previously uncharacterized …
beating. Here we show that DNAAF3 (also known as PF22), a previously uncharacterized …
The nexin-dynein regulatory complex subunit DRC1 is essential for motile cilia function in algae and humans
M Wirschell, H Olbrich, C Werner, D Tritschler… - Nature …, 2013 - nature.com
Primary ciliary dyskinesia (PCD) is characterized by dysfunction of respiratory cilia and
sperm flagella and random determination of visceral asymmetry. Here, we identify the DRC1 …
sperm flagella and random determination of visceral asymmetry. Here, we identify the DRC1 …
Mechanisms of otoconia and otolith development
YW Lundberg, Y Xu, KD Thiessen… - Developmental …, 2015 - Wiley Online Library
Background: Otoconia are bio‐crystals that couple mechanic forces to the sensory hair cells
in the utricle and saccule, a process essential for us to sense linear acceleration and gravity …
in the utricle and saccule, a process essential for us to sense linear acceleration and gravity …
Ciliary motility: regulation of axonemal dynein motors
R Viswanadha, WS Sale… - Cold Spring Harbor …, 2017 - cshperspectives.cshlp.org
Ciliary motility is crucial for the development and health of many organisms. Motility depends
on the coordinated activity of multiple dynein motors arranged in a precise pattern on the …
on the coordinated activity of multiple dynein motors arranged in a precise pattern on the …
CEP41 is mutated in Joubert syndrome and is required for tubulin glutamylation at the cilium
JE Lee, JL Silhavy, MS Zaki, J Schroth, SL Bielas… - Nature …, 2012 - nature.com
Tubulin glutamylation is a post-translational modification that occurs predominantly in the
ciliary axoneme and has been suggested to be important for ciliary function,. However, its …
ciliary axoneme and has been suggested to be important for ciliary function,. However, its …
GRK2: multiple roles beyond G protein-coupled receptor desensitization
G protein-coupled receptor kinases (GRKs) regulate numerous G protein-coupled receptors
(GPCRs) by phosphorylating the intracellular domain of the active receptor, resulting in …
(GPCRs) by phosphorylating the intracellular domain of the active receptor, resulting in …