Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy
This article reviews and summarizes 200 years of Parkinson's disease. It comprises a
relevant history of Dr. James Parkinson's himself and what he described accurately and …
relevant history of Dr. James Parkinson's himself and what he described accurately and …
Emerging therapies in Parkinson disease—repurposed drugs and new approaches
Parkinson disease (PD) treatment options have conventionally focused on dopamine
replacement and provision of symptomatic relief. Current treatments cause undesirable …
replacement and provision of symptomatic relief. Current treatments cause undesirable …
Mechanisms of deep brain stimulation
TM Herrington, JJ Cheng… - Journal of …, 2016 - journals.physiology.org
Deep brain stimulation (DBS) is widely used for the treatment of movement disorders
including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain …
including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain …
Motor symptoms in Parkinson's disease: A unified framework
Parkinson's disease (PD) is characterized by a range of motor symptoms. Besides the
cardinal symptoms (akinesia and bradykinesia, tremor and rigidity), PD patients show …
cardinal symptoms (akinesia and bradykinesia, tremor and rigidity), PD patients show …
Consensus paper: towards a systems-level view of cerebellar function: the interplay between cerebellum, basal ganglia, and cortex
Despite increasing evidence suggesting the cerebellum works in concert with the cortex and
basal ganglia, the nature of the reciprocal interactions between these three brain regions …
basal ganglia, the nature of the reciprocal interactions between these three brain regions …
Pathophysiology of motor dysfunction in Parkinson's disease as the rationale for drug treatment and rehabilitation
F Magrinelli, A Picelli, P Tocco, A Federico… - Parkinson's …, 2016 - Wiley Online Library
Cardinal motor features of Parkinson's disease (PD) include bradykinesia, rest tremor, and
rigidity, which appear in the early stages of the disease and largely depend on …
rigidity, which appear in the early stages of the disease and largely depend on …
The cerebellum in Parkinson's disease
T Wu, M Hallett - Brain, 2013 - academic.oup.com
Parkinson's disease is a chronic progressive neurodegenerative disorder characterized by
resting tremor, slowness of movements, rigidity, gait disturbance and postural instability …
resting tremor, slowness of movements, rigidity, gait disturbance and postural instability …
Parkinson disease subtypes
MA Thenganatt, J Jankovic - JAMA neurology, 2014 - jamanetwork.com
Importance It is increasingly evident that Parkinson disease (PD) is not a single entity but
rather a heterogeneous neurodegenerative disorder. Objective To evaluate available …
rather a heterogeneous neurodegenerative disorder. Objective To evaluate available …
Nonmotor features of Parkinson's disease subtypes
C Marras, KR Chaudhuri - Movement Disorders, 2016 - Wiley Online Library
Parkinson's disease is highly heterogeneous in early clinical features and later outcomes.
This makes classifying subgroups of PD relevant to clinical research and practice …
This makes classifying subgroups of PD relevant to clinical research and practice …
Subthalamic deep brain stimulation sweet spots and hyperdirect cortical connectivity in Parkinson's disease
Objectives Firstly, to identify subthalamic region stimulation clusters that predict maximum
improvement in rigidity, bradykinesia and tremor, or emergence of side-effects; and …
improvement in rigidity, bradykinesia and tremor, or emergence of side-effects; and …