Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy

JA Obeso, M Stamelou, CG Goetz, W Poewe… - Movement …, 2017 - Wiley Online Library
This article reviews and summarizes 200 years of Parkinson's disease. It comprises a
relevant history of Dr. James Parkinson's himself and what he described accurately and …

Emerging therapies in Parkinson disease—repurposed drugs and new approaches

A Elkouzi, V Vedam-Mai, RS Eisinger… - Nature Reviews …, 2019 - nature.com
Parkinson disease (PD) treatment options have conventionally focused on dopamine
replacement and provision of symptomatic relief. Current treatments cause undesirable …

Mechanisms of deep brain stimulation

TM Herrington, JJ Cheng… - Journal of …, 2016 - journals.physiology.org
Deep brain stimulation (DBS) is widely used for the treatment of movement disorders
including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain …

Motor symptoms in Parkinson's disease: A unified framework

AA Moustafa, S Chakravarthy, JR Phillips… - Neuroscience & …, 2016 - Elsevier
Parkinson's disease (PD) is characterized by a range of motor symptoms. Besides the
cardinal symptoms (akinesia and bradykinesia, tremor and rigidity), PD patients show …

Consensus paper: towards a systems-level view of cerebellar function: the interplay between cerebellum, basal ganglia, and cortex

D Caligiore, G Pezzulo, G Baldassarre, AC Bostan… - The Cerebellum, 2017 - Springer
Despite increasing evidence suggesting the cerebellum works in concert with the cortex and
basal ganglia, the nature of the reciprocal interactions between these three brain regions …

Pathophysiology of motor dysfunction in Parkinson's disease as the rationale for drug treatment and rehabilitation

F Magrinelli, A Picelli, P Tocco, A Federico… - Parkinson's …, 2016 - Wiley Online Library
Cardinal motor features of Parkinson's disease (PD) include bradykinesia, rest tremor, and
rigidity, which appear in the early stages of the disease and largely depend on …

The cerebellum in Parkinson's disease

T Wu, M Hallett - Brain, 2013 - academic.oup.com
Parkinson's disease is a chronic progressive neurodegenerative disorder characterized by
resting tremor, slowness of movements, rigidity, gait disturbance and postural instability …

Parkinson disease subtypes

MA Thenganatt, J Jankovic - JAMA neurology, 2014 - jamanetwork.com
Importance It is increasingly evident that Parkinson disease (PD) is not a single entity but
rather a heterogeneous neurodegenerative disorder. Objective To evaluate available …

Nonmotor features of Parkinson's disease subtypes

C Marras, KR Chaudhuri - Movement Disorders, 2016 - Wiley Online Library
Parkinson's disease is highly heterogeneous in early clinical features and later outcomes.
This makes classifying subgroups of PD relevant to clinical research and practice …

Subthalamic deep brain stimulation sweet spots and hyperdirect cortical connectivity in Parkinson's disease

H Akram, SN Sotiropoulos, S Jbabdi, D Georgiev… - Neuroimage, 2017 - Elsevier
Objectives Firstly, to identify subthalamic region stimulation clusters that predict maximum
improvement in rigidity, bradykinesia and tremor, or emergence of side-effects; and …