Sepsis is a deadly inflammatory syndrome caused by an exaggerated immune response to
infection. Much has been focused on host response to pathogens mediated through the …

Preeclampsia is a complex cardiovascular disorder of pregnancy with underlying
multifactorial pathogeneses; however, its etiology is not fully understood. It is characterized …

Paclitaxel is an antineoplastic agent widely used to treat several solid tumor types. The
primary mechanism of action of paclitaxel is based on microtubule stabilization inducing cell …

High blood pressure is present in more than one billion adults worldwide and is the most
important modifiable risk factor of death resulting from cardiovascular disease. While many …

The recognition of invading pathogens and endogenous molecules from damaged tissues
by toll-like receptors (TLRs) triggers protective self-defense mechanisms. However …

Toll‐like receptors (TLRs) are germline‐encoded receptors that are central to innate and
adaptive immune responses. Owing to their vital role in inflammation, TLRs are rational …

Immunosenescence is characterized by deterioration of the immune system caused by
aging which induces changes to innate and adaptive immunity. Immunosenescence affects …

Adverse pregnancy outcomes (APOs)—including pre-term birth, pre-eclampsia, and
intrauterine growth restriction—are common interrelated disorders caused by placental …

Both oxidative stress and inflammation are enhanced in chronic heart failure. Dysfunction of
cardiac mitochondria is a hallmark of heart failure and a leading cause of oxidative stress …

Despite the enormous progress in the understanding of the course of the ischemic stroke
over the last few decades, a therapy that effectively protects neurovascular units (NVUs) and …