Recent applications of DNA microarray technology to toxicology and ecotoxicology

T Lettieri - Environmental health perspectives, 2006 - ehp.niehs.nih.gov
Gene expression is a unique way of characterizing how cells and organisms adapt to
changes in the external environment. The measurements of gene expression levels upon …

Current perspectives on the androgen 5 alpha-dihydrotestosterone (DHT) and 5 alpha-reductases in teleost fishes and amphibians

CJ Martyniuk, S Bissegger, VS Langlois - General and Comparative …, 2013 - Elsevier
The androgen 5 alpha-dihydrotestosterone (DHT) is a steroidogenic metabolite that has
received little attention in non-mammalian species. DHT is produced by the reduction of the …

Gene expression patterns in rainbow trout, Oncorhynchus mykiss, exposed to a suite of model toxicants

SE Hook, AD Skillman, JA Small, IR Schultz - Aquatic Toxicology, 2006 - Elsevier
The increased availability and use of DNA microarrays has allowed the characterization of
gene expression patterns associated with exposure to different toxicants. An important …

Applications for next-generation sequencing in fish ecotoxicogenomics

AC Mehinto, CJ Martyniuk, DJ Spade… - Frontiers in …, 2012 - frontiersin.org
The new technologies for next-generation sequencing (NGS) and global gene expression
analyses that are widely used in molecular medicine are increasingly applied to the field of …

Ecotoxicogenomics: Bridging the gap between genes and populations

A Fedorenkova, JA Vonk, HJR Lenders… - … science & technology, 2010 - ACS Publications
Ecotoxicogenomics might help solving open questions that cannot be answered by standard
ecotoxicity tests currently used in environmental risk assessment. Changes in gene …

Functional genomics of stress responses in fish

P Prunet, MT Cairns, S Winberg… - Reviews in Fisheries …, 2008 - Taylor & Francis
Our understanding of the mechanisms underlying stress responses in fish remains
fragmentary. However, new insights into these mechanisms and their biological significance …

Construction of a robust microarray from a non‐model species largemouth bass, Micropterus salmoides (Lacèpede), using pyrosequencing technology

N Garcia‐Reyero, RJ Griffitt, L Liu, KJ Kroll… - Journal of Fish …, 2008 - Wiley Online Library
A novel custom microarray for largemouth bass (LMB) Micropterus salmoides was designed
with sequences obtained from a normalized cDNA library using the 454 Life Sciences GS …

Identification of a transcriptional fingerprint of estrogen exposure in rainbow trout liver

AD Benninghoff, DE Williams - Toxicological sciences, 2008 - academic.oup.com
The goal of this study was to identify a set of hepatic genes regulated by ligand-dependent
activation of the estrogen receptor in juvenile rainbow trout (Oncorhynchus mykiss). A …

Disruption of classical estrogenic targets in brown trout primary hepatocytes by the model androgens testosterone and dihydrotestosterone

C Lopes, TV Madureira, JF Gonçalves, E Rocha - Aquatic Toxicology, 2020 - Elsevier
Estrogenic effects triggered by androgens have been previously shown in a few studies.
Aromatization and direct binding to estrogen receptors (ERs) are the most proposed …

Application of SSH and a macroarray to investigate altered gene expression in Mytilus edulis in response to exposure to benzo [a] pyrene

M Brown, IM Davies, CF Moffat, JA Craft - Marine environmental research, 2006 - Elsevier
The lack of genomic resources for aquatic invertebrates restricts their use as sentinel
species in coastal environments. It is known that where genomic data are not available …