Ribosomal protein genes are among the most highly expressed genes in most cell types.
Their products are generally essential for ribosome synthesis, which is the cornerstone for …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

We describe complete design of a synthetic eukaryotic genome, Sc2. 0, a highly modified
Saccharomyces cerevisiae genome reduced in size by nearly 8%, with 1.1 megabases of …

A recent slew of ENCyclopedia Of DNA Elements (ENCODE) Consortium publications,
specifically the article signed by all Consortium members, put forward the idea that more …

Introns are ubiquitous features of all eukaryotic cells. Introns need to be removed from
nascent messenger RNA through the process of splicing to produce functional proteins …

Recent advances in DNA synthesis technology have enabled the construction of novel
genetic pathways and genomic elements, furthering our understanding of system-level …

INTRODUCTION Although much effort has been devoted to studying yeast in the past few
decades, our understanding of this model organism is still limited. Rapidly developing DNA …

Spliceosomal introns are ubiquitous non-coding RNAs that are typically destined for rapid
debranching and degradation. Here we describe 34 excised introns in Saccharomyces …

Transcription is a source of genetic instability that can notably result from the formation of
genotoxic DNA: RNA hybrids, or R-loops, between the nascent mRNA and its template. Here …

Considerable progress in our understanding of yeast genomes and their evolution has been
made over the last decade with the sequencing, analysis, and comparisons of numerous …