Natural products (NPs) have historically played a primary role in the discovery of small-
molecule drugs. However, due to the advent of other methodologies and the drawbacks of …

Conspectus Securinega alkaloids, composed of more than 100 members characterized by
the compact tetracyclic scaffold, have fascinated the synthetic community with their structural …

Repetitive isolation of known compounds remains a major challenge in natural-product-
based drug discovery. LC-MS/MS-based molecular networking has become a highly …

We completed the synthesis of dimeric high-oxidation-state securinega alkaloid
flueggeacosine B via two synthetic routes from allosecurinine. The first-generation synthesis …

Large-scale metabolite annotation is a bottleneck in untargeted metabolomics. Here, we
present a structure-guided molecular network strategy (SGMNS) for deep annotation of …

Securinega alkaloids are indolizidine alkaloids extracted from the leaf and root of an Asian
plant, Securinega suffruticosa. Since its discovery in 1956 by Russian scientists, numerous …

Natural products (NPs) historically serve as a valuable and productive source of bioactive
compounds for drug development. The discovery of a range of alkaloids in the early 1800s …

Tripterygium wilfordii Hook F from the family Celastraceae is a traditional Chinese medicine
(TCM) whose principal chemical constituents are terpenoids, including sesquiterpene …

Guided by MS/MS molecular networks strategy, chlospicenes A and B (1 and 2), the first
example of cyclopropane moiety cracked lindenane sesquiterpene Michael addition dimers …

Covering: up to March 2023Machine learning (ML) has emerged as a popular tool for
analyzing the structures of natural products (NPs). This review presents a summary of the …