Bacterial outer membrane vesicles as a platform for biomedical applications: An update

M Li, H Zhou, C Yang, Y Wu, X Zhou, H Liu… - Journal of Controlled …, 2020 - Elsevier
Outer membrane vesicles (OMVs) are produced by Gram-negative bacteria both in vitro and
in vivo. OMVs are nano-sized spherical vehicles formed by lipid bilayer membranes and …

Outer membrane vesicles (OMVs) produced by gram‐negative bacteria: structure, functions, biogenesis, and vaccine application

N Furuyama, MP Sircili - BioMed Research International, 2021 - Wiley Online Library
Gram‐negative bacteria produce outer membrane vesicles (OMVs) with 10 to 300 nm of
diameter. The contribution of OMVs to bacterial pathogenesis is a topic of great interest, and …

Current Stage in the Development of Klebsiella pneumoniae Vaccines

L Assoni, R Girardello, TR Converso… - Infectious diseases and …, 2021 - Springer
Klebsiella pneumoniae is a bacterium capable of colonizing mucous membranes, causing
serious infections. Widespread antibiotic resistance in K. pneumoniae—either through …

Bacterial extracellular vesicles: Understanding biology promotes applications as nanopharmaceuticals

LP Jahromi, G Fuhrmann - Advanced drug delivery reviews, 2021 - Elsevier
Extracellular vesicle (EV)-mediated communication between proximal and distant cells is a
highly conserved characteristic in all of the life domains, including bacteria. These vesicles …

Outer Membrane Vesicles Derived from Klebsiella pneumoniae Are a Driving Force for Horizontal Gene Transfer

F Dell'Annunziata, C Dell'Aversana, N Doti… - International Journal of …, 2021 - mdpi.com
Gram-negative bacteria release Outer Membrane Vesicles (OMVs) into the extracellular
environment. Recent studies recognized these vesicles as vectors to horizontal gene …

The application of the CRISPR-Cas system in antibiotic resistance

S Tao, H Chen, N Li, W Liang - Infection and drug resistance, 2022 - Taylor & Francis
The emergence and global epidemic of antimicrobial resistance (AMR) poses a serious
threat to global public health in recent years. AMR genes are shared between bacterial …

Evaluation of antibiotic resistance and biofilm production among clinical strain isolated from medical devices

V Folliero, G Franci, F Dell'Annunziata… - International journal …, 2021 - Wiley Online Library
Microbial biofilms pose a serious threat to patients requiring medical devices (MDs).
Prolonged periods of implantation carry a high risk of device‐related infections (DRIs) …

Gene transfer potential of outer membrane vesicles of gram-negative bacteria

F Dell'Annunziata, V Folliero, R Giugliano… - International journal of …, 2021 - mdpi.com
The increasing spread of multidrug-resistant pathogenic bacteria is one of the major threats
to public health worldwide. Bacteria can acquire antibiotic resistance and virulence genes …

Bacterial outer membrane vesicles as a versatile tool in vaccine research and the fight against antimicrobial resistance

Z Zhu, F Antenucci, KR Villumsen, AM Bojesen - MBio, 2021 - Am Soc Microbiol
Gram-negative bacteria include a number of pathogens that cause disease in humans and
animals. Although antibiotics are still effective in treating a considerable range of infections …

Exploring the journey: A comprehensive review of vaccine development against Klebsiella pneumoniae

B Douradinha - Microbiological Research, 2024 - Elsevier
Klebsiella pneumoniae, a prominent nosocomial pathogen, poses a critical global health
threat due to its multidrug-resistant (MDR) and hypervirulent strains. This comprehensive …