Endurance exercise is a widely accessible, low-cost intervention with a variety of benefits to
multiple organ systems. Exercise improves multiple indices of physical performance and …

Parkinson's disease (PD) is a neurodegenerative disorder with symptoms that progressively
worsen with age. Pathologically, PD is characterized by the aggregation of α-synuclein in …

The toxicity of misfolded proteins and mitochondrial dysfunction are pivotal factors that
promote age-associated functional neuronal decline and neurodegenerative disease …

Regular physical exercise is the most efficient and accessible intervention known to promote
healthy aging in humans. The molecular and cellular mechanisms that mediate system-wide …

In the aging brain, many of the alterations underlying cognitive and behavioral decline
remain opaque. Caenorhabditis elegans offers a powerful model for aging research, with a …

Many nutritional interventions that increase lifespan are also proposed to postpone age-
related declines in motor and cognitive function. Potential sources of anti-aging compounds …

Aging is characterized by a functional decline in organism fitness over time due to a complex
combination of genetic and environmental factors. With an increasing elderly population at …

The ellipsoid body (EB) of the insect brain performs pivotal functions in controlling
navigation. Input and output of the EB is provided by multiple classes of R-neurons (now …

Introduction Human neurodevelopmental and neurodegenerative diseases (NDevDs and
NDegDs, respectively) encompass a broad spectrum of disorders affecting the nervous …

Abstract Regulatory Factor X (RFX) transcription factors (TFs) are best known for activating
genes required for ciliogenesis in both vertebrates and invertebrates. In humans, eight RFX …