The CRISPR system is a revolutionary genome editing tool that has the potential to
revolutionize the field of cancer research and therapy. The ability to precisely target and edit …

Chimeric antigen receptor (CAR)-engineered T (CAR-T) cells have obtained prominent
achievement in the clinical immunotherapy of hematological malignant tumors, leading to a …

Inefficient knock-in of transgene cargos limits the potential of cell-based medicines. In this
study, we used a CRISPR nuclease that targets a site within an exon of an essential gene …

Glioblastoma (GBM) is the most aggressive and malignant primary brain tumor in adults.
Despite multimodality treatment involving surgical resection, radiation therapy …

Simple Summary New approaches in adoptive immunotherapy using chimeric antigen
receptor (CAR)-modified cells have been developing very quickly in recent years, entering …

Antitumor activity of immune cells such as T cells and NK cells has made them auspicious
therapeutic regimens for adaptive cancer immunotherapy. Enhancing their cytotoxic effects …

In recent years, the use of adeno‐associated viruses (AAVs) as vectors for gene and cell
therapy has increased, leading to a rise in the amount of AAV vectors required during pre …

Chimeric antigen receptor (CAR) T cell therapy has been a great success in CD19+
hematological diseases. Natural killer (NK) CAR cells offer an alternative to CAR T cells with …

Melanoma is among the most lethal forms of cancer, accounting for 80% of deaths despite
comprising just 5% of skin cancer cases. Treatment options remain limited due to the genetic …

There are lots of gene editing tools for targeting genome sequences. Some are almost
known, and most are a complete mystery and undiscovered. CRISPR/Cas editing tools have …