Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Alzheimer's disease (AD) challenges our society with an annual estimated cost of $1.08
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …

Aggregation of amyloid-β (Aβ) by self-assembly into oligomers or amyloids is a central event
in Alzheimer's disease. Coordination of transition-metal ions, mainly copper and zinc, to Aβ …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the elderly.
Zinc (Zn) ion interacts with the pathogenic hallmark, amyloid-β (Aβ), and is enriched in …

In the last two decades, the amyloid hypothesis, ie, the abnormal accumulation of toxic Aβ
assemblies in the brain, has been considered the mainstream concept sustaining research …

Identifying the structures of membrane bound proteins is critical to understanding their
function in healthy and diseased states. We introduce a surface enhanced Raman …

Small oligomers of the amyloid β (Aβ) peptide, rather than the monomers or the fibrils, are
suspected to initiate Alzheimer′ s disease (AD). However, their low concentration and …

In humans, β-amyloid and islet amyloid polypeptide (IAPP, also known as amylin)
aggregations are linked to Alzheimer's disease and type-2 diabetes, respectively. There is …

Neurodegenerative diseases, such as Alzheimer's disease (AD) and various types of
amyloidosis, are incurable; therefore, understanding the mechanisms of amyloid …

Recent evidence suggests involvement of biometal homeostasis in the pathological
mechanisms in Alzheimer's disease (AD). For example, increased intracellular copper or …