Human serum albumin (HSA), the most abundant protein in plasma, is a monomeric multi-
domain macromolecule, representing the main determinant of plasma oncotic pressure and …

Biologists were puzzled by the discovery of left-handed Z-DNA because it seemed
unnecessary. Z-DNA was stabilized by the negative supercoiling generated by transcription …

Publisher Summary This chapter discusses the structure and function of DNA. DNA occupies
a critical role in cells, because it is the source of all intrinsic genetic information. Chemically …

MANY indirect methods have been developed to study the constitu-tion and conformation of
macromolecules inside the living cell. Direct analysis by Raman spectroscopy is an ideal …

The idea that DNA might have both right-and left-handed double helical conformations is not
a new one. In fact, it arose almost immediately with the formulation of the double helix by …

Repetitive DNA motifs are abundant in the genomes of various species and have the
capacity to adopt non-canonical (ie, non-B) DNA structures. Several non-B DNA structures …

By Southern blotting and hybridization analysis using 32P-labeled poly (dT-dG). poly (dC-
dA) as a probe, we have found, in eukaryotic genomes, a huge number of stretches of dT-dG …

We have obtained a polyclonal antibody that recognizes a major polypeptide component of
chicken mitotic chromosome scaffolds. This polypeptide migrates in SDS PAGE with Mr …

Daunorubicin and doxorubicin, two antibiotics belonging to the anthracycline group, are
widely used in human cancer chemotherapy. Their activity has been attributed mainly to …

We have cloned the major noncoding region of human mitochondrial DNA (mtDNA) from 11
human placentas. Partial nucleotide sequences of five of these clones have been …