Abstract Dipeptidyl peptidase-4 (DPP-4) is a membrane-associated peptidase, also known
as CD26. DPP-4 has widespread organ distribution throughout the body and exerts …

The Trypanosomatidae family includes the genera Trypanosoma and Leishmania,
protozoan parasites displaying complex digenetic life cycles requiring a vertebrate host and …

Background CD8+ T cells play an essential role against tumors but the role of human CD8+
CD26+ T cell subset against tumors, in particular, haematological cancers such as chronic …

Recently, there has been a renewed interest in the development of new drugs for the
treatment of leishmaniasis. This has spurred the need for pharmacodynamic markers to …

Abstract Dipeptidyl-peptidase-4 (DPP-4) is an enzyme having various properties and
physiological roles in lipid accumulation, resistance to anticancer agents, and immune …

Biomarkers are incorporated ubiquitously into clini-cal practice as surrogate endpoints of
physiologic and pathologic processes that cannot be measured directly. For example, a lipid …

Intracellular survival of Leishmania donovani demands rapid production of host ATP for its
sustenance. However, a gradual decrease in intracellular ATP in spite of increased …

Materials and Methods: Two doses of recombinant IL (rIL)-17A and/or IFN-γ were
administered intraperitoneally after/at 1 week interval and then the mice were challenged …

The cross-reactivity of mycobacterial antigens in immune-based diagnostic assays has been
a major concern and a criticism of the current tests that are used for the detection of …

Purpose Leishmania, the causative organisms for leishmaniasis, reside in host
macrophages and survive by modulating the microbicidal pathways via attenuation of the …