Metabolomics is the comprehensive assessment of endogenous metabolites and attempts to
systematically identify and quantify metabolites from a biological sample. Small-molecule …

Metabolomics offers a revolutionary framework for phenotyping individuals at a molecular
level that is needed for new breakthroughs in cell biology and personalized medicine. 1− 3 …

Biological systems are increasingly being studied in a holistic manner, using omics
approaches, to provide quantitative and qualitative descriptions of the diverse collection of …

Metabolomics, one of the 'omic'sciences in systems biology, is the global assessment and
validation of endogenous small-molecule metabolites within a biologic system. Analysis of …

For long time, organic acids were underestimated. However, during last two decades there
is an increasing interest of natural compounds having antioxidant, antimicrobial and anti …

Nowadays, there is a growing interest in deeply understanding biological mechanisms not
only at the molecular level (biological components) but also the effects of an ongoing …

The present review gives an introduction into the concept of metabolomics and provides an
overview of the analytical tools applied in non-targeted metabolomics with a focus on liquid …

Obesity and diabetes arise from an intricate interplay between both genetic and
environmental factors. It is well recognized that obesity plays an important role in the …

Capillary zone electrophoresis-mass spectrometry (CE-MS) is a mature analytical tool for the
efficient profiling of (highly) polar and ionizable compounds. However, the use of CE-MS in …

Highlights•CE–MS is an attractive analytical tool for analyzing the polar ionogenic
metabolome.•A novel sheathless interface for CE–MS allows highly sensitive metabolic …