Growth and division of the peptidoglycan matrix

PDA Rohs, TG Bernhardt - Annual review of microbiology, 2021 - annualreviews.org
Most bacteria are surrounded by a peptidoglycan cell wall that defines their shape and
protects them from osmotic lysis. The expansion and division of this structure therefore plays …

The bacterial cell wall: from lipid II flipping to polymerization

S Kumar, A Mollo, D Kahne, N Ruiz - Chemical reviews, 2022 - ACS Publications
The peptidoglycan (PG) cell wall is an extra-cytoplasmic glycopeptide polymeric structure
that protects bacteria from osmotic lysis and determines cellular shape. Since the cell wall …

Cryo-EM structure of the bacterial divisome core complex and antibiotic target FtsWIQBL

L Käshammer, F van den Ent, M Jeffery, NL Jean… - Nature …, 2023 - nature.com
In most bacteria, cell division relies on the synthesis of new cell wall material by the
multiprotein divisome complex. Thus, at the core of the divisome are the transglycosylase …

β-Lactams against the Fortress of the Gram-Positive Staphylococcus aureus Bacterium

JF Fisher, S Mobashery - Chemical reviews, 2020 - ACS Publications
The biological diversity of the unicellular bacteria—whether assessed by shape, food,
metabolism, or ecological niche—surely rivals (if not exceeds) that of the multicellular …

Peptidoglycan: structure, synthesis, and regulation

S Garde, PK Chodisetti, M Reddy - EcoSal Plus, 2021 - Am Soc Microbiol
Peptidoglycan is a defining feature of the bacterial cell wall. Initially identified as a target of
the revolutionary beta-lactam antibiotics, peptidoglycan has become a subject of much …

[HTML][HTML] Limits and barriers to adaptation to climate variability and change in Bangladeshi coastal fishing communities

MM Islam, S Sallu, K Hubacek, J Paavola - Marine Policy, 2014 - Elsevier
Limits and barriers to adaptation restrict people's ability to address the negative impacts of
climate change or manage risks in a way that maximises their wellbeing. There is a lack of …

A conserved subcomplex within the bacterial cytokinetic ring activates cell wall synthesis by the FtsW-FtsI synthase

LS Marmont, TG Bernhardt - Proceedings of the National …, 2020 - National Acad Sciences
Cell division in bacteria is mediated by a multiprotein assembly called the divisome. A major
function of this machinery is the synthesis of the peptidoglycan (PG) cell wall that caps the …

Intrinsically disordered protein regions are required for cell wall homeostasis in Bacillus subtilis

YR Brunet, C Habib, AP Brogan, L Artzi… - Genes & …, 2022 - genesdev.cshlp.org
Intrinsically disordered protein regions (IDRs) have been implicated in diverse nuclear and
cytoplasmic functions in eukaryotes, but their roles in bacteria are less clear. Here, we report …

Structural basis of lipopolysaccharide maturation by the O-antigen ligase

KU Ashraf, R Nygaard, ON Vickery, SK Erramilli… - Nature, 2022 - nature.com
The outer membrane of Gram-negative bacteria has an external leaflet that is largely
composed of lipopolysaccharide, which provides a selective permeation barrier, particularly …

Emerging structural insights into C-type glycosyltransferases

JAN Alexander, KP Locher - Current Opinion in Structural Biology, 2023 - Elsevier
Glycosyltransferases of the C superfamily (GT-Cs) are enzymes found in all domains of life.
They catalyse the stepwise synthesis of oligosaccharides or the transfer of assembled …