Microtubules are non-covalent mesoscale polymers central to the eukaryotic cytoskeleton.
Microtubule structure, dynamics, and mechanics are modulated by a cell's choice of tubulin …

The αβ-tubulin heterodimer, the building block of microtubules, is subject to a large number
of post-translational modifications, comparable in diversity to the intensively studied histone …

Microtubules create diverse arrays with specific cellular functions such as the mitotic spindle,
cilia, and bundles inside neurons. How microtubules are regulated to enable specific …

Tubulin, the subunit protein of microtubules, is an α/β heterodimer. In many organisms, both
α and β exist in numerous isotypic forms encoded by different genes. In addition, both α and …

Microtubules–polymers of tubulin–perform essential functions, including regulation of cell
shape, intracellular transport and cell motility. How microtubules are adapted to perform …

Tubulin posttranslational modifications represent an important mechanism involved in the
regulation of microtubule functions. The most widespread among them are detyrosination …

Although most eukaryotic cells can express multiple isotypes of αβ-tubulin, the significance
of this diversity has not always been apparent. Recent data indicate that particular αβ-tubulin …

Tubulin, the protein subunit of microtubules (MTs), is an α/β heterodimer. In this chapter, a
hypothesis on the evolution of the tubulin molecule is proposed, based in part on recent …

How microtubule-associated motor proteins are regulated is not well understood. A potential
mechanism for spatial regulation of motor proteins is provided by posttranslational …

The in vivo significance of microtubule severing and the mechanisms governing its spatial
regulation are not well understood. In Tetrahymena, a cell type with elaborate microtubule …