Metabotropic glutamate receptor 5 (mGluR5) is ubiquitously expressed in brain regions
responsible for memory and learning. It plays a key role in modulating rapid changes in …

Metabotropic glutamate (mGlu) receptors respond to glutamate, the major excitatory
neurotransmitter in the mammalian brain, mediating a modulatory role that is critical for …

The prevalence, presentation, and progression of Alzheimer's disease (AD) differ between
men and women, although β-amyloid (Aβ) deposition is a pathological hallmark of AD in …

Alzheimer's disease (AD) is a progressive neurodegenerative disease that is difficult to treat.
Extracellular amyloid is the principal pathological criterion for the diagnosis of AD. Amyloid β …

The type 5 metabotropic glutamate receptor, mGlu5, has been proposed as a potential
therapeutic target for the treatment of several neurodegenerative diseases. In preclinical …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease and is
characterized by a progressive cognitive decline in affected individuals. Current therapeutic …

Different data suggest that microglia may participate in the drug addiction process as these
cells respond to neurochemical changes induced by the administration of these substances …

Glutamate, the major excitatory neurotransmitter in the brain exerts its effects via both
ionotropic glutamate receptors and metabotropic glutamate receptors (mGluRs). There are …

Toxoplasma gondii chronic infection is characterized by the establishment of tissue cysts in
the brain and increased levels of IFN-γ, which can lead to brain circuitry interference and …

Despite fundamental differences in disease course and outcomes, neurodevelopmental
(autism spectrum disorders–ASD) and neurodegenerative disorders (Alzheimer's disease …