Abstract Glutathione peroxidase 4 (GPx4) moonlights as structural protein and antioxidase
that powerfully inhibits lipid oxidation. In the past years, it is considered as a key regulator of …

The oocyte is recognised as the largest cell in mammalian species and other multicellular
organisms. Mitochondria represent a high proportion of the cytoplasm in oocytes and …

Abstract Glutathione peroxidase 4 (GPx4) is an antioxidant enzyme reported as an inhibitor
of ferroptosis, a recently discovered non-apoptotic form of cell death. This pathway was …

Balancing cell survival and cell death is fundamental to development and homeostasis. Cell
death is regulated by multiple interconnected signaling pathways and molecular …

Abstract Docosahexaenoic acid (C22: 6n-3, DHA) is a long-chain polyunsaturated fatty acid
of marine origin fundamental for the formation and function of the nervous system …

Ferroptosis is a unique regulated cell death defined by the intracellular iron overload and
distinct biological features compared with other well-known programmed cell death …

Abstract Docosahexaenoic acid (DHA, C22: 6, ω-3) is a highly polyunsaturated omega-3
fatty acid. It is concentrated in neuronal brain membranes, for which reason it is also referred …

Ferroptosis is a unique form of programmed death, characterised by cytosolic accumulation
of iron, lipid hydroperoxides and their metabolites, and effected by the fatal peroxidation of …

The nonenzymatic adduction of malondialdehyde (MDA) to the protein amino groups leads
to the formation of malondialdehyde-lysine (MDALys). The degree of unsaturation of …

DHA (docosahexaenoic acid) is perhaps the most pleiotropic molecule in nerve cell biology.
This long-chain highly unsaturated fatty acid has evolved to accomplish essential functions …