Current trends in computational quantum chemistry studies on antioxidant radical scavenging activity

M Spiegel - Journal of Chemical Information and Modeling, 2022 - ACS Publications
The antioxidative nature of chemicals is now routinely studied using computational quantum
chemistry. Scientists are constantly proposing new approaches to investigate those …

Antioxidant motifs in flavonoids: O–H versus C–H bond dissociation

QV Vo, PC Nam, NM Thong, NT Trung, CTD Phan… - ACS …, 2019 - ACS Publications
Flavonoids provide potential health benefits due to their antioxidant properties. The
antioxidant activity of natural flavonoids is primarily exerted by phenolic hydroxyl groups; …

[HTML][HTML] Primary and secondary antioxidant properties of scutellarin and scutellarein in water and lipid-like environments: A theoretical investigation

M Spiegel, T Marino, M Prejanò, N Russo - Journal of Molecular Liquids, 2022 - Elsevier
The scavenging capability of scutellarin flavonoid against the OOH radical has been studied,
at Density Functional level of theory, by considering different reaction mechanisms in both …

Theoretical study on the free radical scavenging potency and mechanism of natural coumestans: Roles of substituent, noncovalent interaction and solvent

M Chen, Z Li, G Sun, S Jin, X Hao, C Zhang, L Liu… - Phytochemistry, 2023 - Elsevier
The free radical scavenging potency and mechanisms of seven representative natural
coumestans were systematically evaluated using density functional theory (DFT) approach …

Antioxidant and copper-chelating power of new molecules suggested as multiple target agents against Alzheimer's disease. A theoretical comparative study

M Spiegel, T Marino, M Prejanò… - Physical Chemistry …, 2022 - pubs.rsc.org
In this study, the scavenging activity against OOH radicals and the copper-chelating ability of
two new synthesized molecules (named L1 and L2) that can act as multiple target agents …

On the scavenging ability of scutellarein against the OOH radical in water and Lipid-like environments: A Theoretical study

M Spiegel, T Marino, M Prejanò, N Russo - Antioxidants, 2022 - mdpi.com
The antioxidant capability of scutellarein, a flavonoid extracted from different plants of the
Scutellaria family, was computationally predicted by considering its reaction with the OOH …

Computational investigation on the antioxidant activities and on the Mpro SARS-CoV-2 non-covalent inhibition of isorhamnetin

M Spiegel, G Ciardullo, T Marino, N Russo - Frontiers in Chemistry, 2023 - frontiersin.org
In the present work, we report a computational study on some important chemical properties
of the flavonoid isorhamnetin, used in traditional medicine in many countries. In the course …

In silico study of the radical scavenging activities of natural indole-3-carbinols

QV Vo, A Mechler - Journal of Chemical Information and Modeling, 2019 - ACS Publications
Enzymatic hydrolysis of indole glucosinolates in the human body yields the Indole-3-
carbinol family of compounds (I3Cs). I3Cs are implicated in the self-healing processes of the …

Insight into antioxidant and photoprotective properties of natural compounds from marine fungus

DQ Dao, TTT Phan, TLA Nguyen… - Journal of chemical …, 2020 - ACS Publications
This computational and experimental work aims to elucidate physicochemical and
photophysical natures of free radical scavenging and ultraviolet radiation (UVR) filtering …

[HTML][HTML] On the dual role of (+)-catechin as primary antioxidant and inhibitor of viral proteases

G Ciardullo, C Orlando, N Russo, E Marchese… - Computers in Biology …, 2024 - Elsevier
Natural antioxidants have become the subject of many investigations due to the role that
they play in the reduction of oxidative stress. Their main scavenging mechanisms concern …