[HTML][HTML] Behavioral assessment of sensory, motor, emotion, and cognition in rodent models of intracerebral hemorrhage

X Shi, H Bai, J Wang, J Wang, L Huang, M He… - Frontiers in …, 2021 - frontiersin.org
Intracerebral hemorrhage (ICH) is the second most common type of stroke and has one of
the highest fatality rates of any disease. There are many clinical signs and symptoms after …

[HTML][HTML] NDP-MSH binding melanocortin-1 receptor ameliorates neuroinflammation and BBB disruption through CREB/Nr4a1/NF-κB pathway after intracerebral …

X Wu, S Fu, Y Liu, H Luo, F Li, Y Wang, M Gao… - Journal of …, 2019 - Springer
Background Neuroinflammation and blood-brain barrier (BBB) disruption are two vital
mechanisms of secondary brain injury following intracerebral hemorrhage (ICH). Recently …

The pros and cons of motor, memory, and emotion-related behavioral tests in the mouse traumatic brain injury model

R Zhang, J Wang, L Huang, TJ Wang… - Neurological …, 2022 - Taylor & Francis
Traumatic brain injury (TBI) is a medical emergency with high morbidity and mortality. Motor,
memory, and emotion-related deficits are common symptoms following TBI, yet treatment is …

Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several …

SS Karuppagounder, I Alim, SJ Khim… - Science translational …, 2016 - science.org
Disability or death due to intracerebral hemorrhage (ICH) is attributed to blood lysis,
liberation of iron, and consequent oxidative stress. Iron chelators bind to free iron and …

Activation of the melanocortin‐1 receptor by NDP‐MSH attenuates oxidative stress and neuronal apoptosis through PI3K/Akt/Nrf2 pathway after intracerebral …

S Fu, X Luo, X Wu, T Zhang, L Gu… - Oxidative medicine …, 2020 - Wiley Online Library
Oxidative stress and neuronal apoptosis play crucial roles in secondary brain injury (SBI)
after intracerebral hemorrhage (ICH). Recently, Nle4‐D‐Phe7‐α‐melanocyte‐stimulating …

[HTML][HTML] Activation of dopamine D1 receptor decreased NLRP3-mediated inflammation in intracerebral hemorrhage mice

T Wang, D Nowrangi, L Yu, T Lu, J Tang, B Han… - Journal of …, 2018 - Springer
Background Inflammasomes are involved in diverse inflammatory diseases. Previous study
reported that the neurotransmitter dopamine inhibited NLRP3 inflammasome activation via …

[HTML][HTML] Dynamic process of secondary pulmonary infection in mice with intracerebral hemorrhage

H Zhang, Y Huang, X Li, X Han, J Hu, B Wang… - Frontiers in …, 2021 - frontiersin.org
Stroke is a common central nervous system disease in clinical practice. Stroke patients often
have infectious complications, such as pneumonia and infections of the urinary tract and …

[HTML][HTML] Buyang huanwu decoction promotes angiogenesis via vascular endothelial growth factor receptor-2 activation through the PI3K/Akt pathway in a mouse …

HJ Cui, AL Yang, HJ Zhou, C Wang, JK Luo… - … and Alternative Medicine, 2015 - Springer
Background Intracerebral hemorrhage (ICH) is a fatal subtype of stroke that lacks effective
treatments. Angiogenesis following ICH is an important response mediating brain recovery …

Ghrelin attenuates secondary brain injury following intracerebral hemorrhage by inhibiting NLRP3 inflammasome activation and promoting Nrf2/ARE signaling …

Y Cheng, B Chen, W Xie, Z Chen, G Yang, Y Cai… - International …, 2020 - Elsevier
Ghrelin, a brain-gut peptide, has been proven to exert neuroprotection in different kinds of
neurological diseases; however, its role and the potential molecular mechanisms in …

Gastrodin attenuates neuronal apoptosis and neurological deficits after experimental intracerebral hemorrhage

X Liu, C Wu, X Hu, T Wang, X Jin, S Ke, E Wang… - Journal of Stroke and …, 2020 - Elsevier
Objective: Gastrodin, a glucoside of gastrodigenin, inhibits cerebral oxidant stress and
apoptosis in multiple central nervous system injury, but its effect in intracerebral hemorrhage …