As part of the neurovascular unit, the blood-brain barrier (BBB) is a unique, dynamic
regulatory boundary that limits and regulates the exchange of molecules, ions, and cells …

Ischemic stroke generates an immune response that contributes to neuronal loss as well as
tissue repair. This is a complex process involving a range of cell types and effector …

Alzheimer's disease (AD) is a neurodegenerative disorder, most cases of which lack a clear
causative event. This has made the disease difficult to characterize and, thus, diagnose …

Ischemic stroke is the third cause of death in the developed countries and the main reason
of severe disability. Brain ischemia leads to the production of damage-associated molecular …

While the mainstay of acute stroke treatment includes revascularization via recombinant
tissue plasminogen activator or mechanical thrombectomy, only a minority of stroke patients …

The effects of current treatment strategies for ischemic stroke are weakened by ischemia-
reperfusion (I/R) injury. Effective treatments targeting I/R injury are still insufficient …

The brain vasculature has been increasingly recognized as a key player that directs brain
development, regulates homeostasis, and contributes to pathological processes. Following …

The innate immune system plays a dualistic role in the evolution of ischemic brain damage
and has also been implicated in ischemic tolerance produced by different conditioning …

After an acute ischemic stroke (AIS), inflammatory processes are able to concomitantly
induce both beneficial and detrimental effects. In this narrative review, we updated evidence …

Our knowledge of the pathophysiology about traumatic brain injury (TBI) is still limited.
Neutrophils, as the most abundant leukocytes in circulation and the first-line transmigrated …