Tissues have a natural capacity to replace dying cells and to heal wounds. This ability
resides in resident stem cells, which self-renew, preserve, and repair their tissue during …

Membrane-type matrix metalloproteinases (MT-MMPs) form a subgroup of the matrix
metalloproteinase (MMP) family, and there are 6 MT-MMPs in humans. MT-MMPs are further …

Wound healing is essential to repair the skin after injury. In the epidermis, distinct stem cells
(SCs) populations contribute to wound healing. However, how SCs balance proliferation …

It is now becoming apparent that dynamic changes occur within the interstitium that directly
contribute to adverse myocardial remodeling following myocardial infarction (MI), with …

MT1-MMP is a membrane-bound matrix metalloproteinase (MT-MMP) capable of mediating
pericellular proteolysis of extracellular matrix components. MT1-MMP is therefore thought to …

Osteopontin (OPN) is an arginine-glycine-aspartate (RGD)-containing glycoprotein encoded
by the gene secreted phosphoprotein 1 (spp1). spp1 is expressed during embryogenesis …

Inflammation and angiogenesis are frequently coupled in pathological situations such as
atherosclerosis, diabetes, and arthritis. The inflammatory response increases capillary …

During angiogenesis, endothelial cells penetrate fibrin barriers via undefined proteolytic
mechanisms. We demonstrate that the fibrinolytic plasminogen activator (PA)-plasminogen …

As cancer cells traverse collagen-rich extracellular matrix (ECM) barriers and intravasate,
they adopt a fibroblast-like phenotype and engage undefined proteolytic cascades that …

The name myofibroblast was proposed several years ago for fibroblastic cells located within
granulation tissue and exhibiting an important cytoplasmic microfilamentous apparatus [1 …