Causes of mutation rate variability in plant genomes
D Quiroz, M Lensink, DJ Kliebenstein… - Annual Review of …, 2023 - annualreviews.org
Mutation is the source of all heritable diversity, the essential material of evolution and
breeding. While mutation rates are often regarded as constant, variability in mutation rates …
breeding. While mutation rates are often regarded as constant, variability in mutation rates …
[HTML][HTML] A fork in the road: Where homologous recombination and stalled replication fork protection part ways
S Tye, GE Ronson, JR Morris - Seminars in Cell & Developmental Biology, 2021 - Elsevier
In response to replication hindrances, DNA replication forks frequently stall and are
remodelled into a four-way junction. In such a structure the annealed nascent strand is …
remodelled into a four-way junction. In such a structure the annealed nascent strand is …
FIGNL1-FIRRM is essential for meiotic recombination and prevents DNA damage-independent RAD51 and DMC1 loading
A Zainu, P Dupaigne, S Bouchouika, J Cau… - Nature …, 2024 - nature.com
During meiosis, nucleoprotein filaments of the strand exchange proteins RAD51 and DMC1
are crucial for repairing SPO11-generated DNA double-strand breaks (DSBs) by …
are crucial for repairing SPO11-generated DNA double-strand breaks (DSBs) by …
Different NIPBL requirements of cohesin-STAG1 and cohesin-STAG2
D Alonso-Gil, A Cuadrado, D Giménez-Llorente… - Nature …, 2023 - nature.com
Cohesin organizes the genome through the formation of chromatin loops. NIPBL activates
cohesin's ATPase and is essential for loop extrusion, but its requirement for cohesin loading …
cohesin's ATPase and is essential for loop extrusion, but its requirement for cohesin loading …
DNA replication and replication stress response in the context of nuclear architecture
D González-Acosta, M Lopes - Chromosoma, 2024 - Springer
The DNA replication process needs to be coordinated with other DNA metabolism
transactions and must eventually extend to the full genome, regardless of chromatin status …
transactions and must eventually extend to the full genome, regardless of chromatin status …
Specialized functions of cohesins STAG1 and STAG2 in 3D genome architecture
A Cuadrado, A Losada - Current opinion in genetics & development, 2020 - Elsevier
Cohesin is a complex conserved in evolution that entraps DNA. Originally identified for its
role in sister chromatid cohesion, it is currently considered a key player in 3D genome …
role in sister chromatid cohesion, it is currently considered a key player in 3D genome …
A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination
Mutations in the tumour suppressor gene BRCA2 are associated with predisposition to
breast and ovarian cancers. BRCA2 has a central role in maintaining genome integrity by …
breast and ovarian cancers. BRCA2 has a central role in maintaining genome integrity by …
Cohesin mutations in cancer: emerging therapeutic targets
J Antony, CV Chin, JA Horsfield - International journal of molecular …, 2021 - mdpi.com
The cohesin complex is crucial for mediating sister chromatid cohesion and for hierarchal
three-dimensional organization of the genome. Mutations in cohesin genes are present in a …
three-dimensional organization of the genome. Mutations in cohesin genes are present in a …
The dynamic role of cohesin in maintaining human genome architecture
Recent advances in genomic and imaging techniques have revealed the complex manner of
organizing billions of base pairs of DNA necessary for maintaining their functionality and …
organizing billions of base pairs of DNA necessary for maintaining their functionality and …
PDS5A and PDS5B in cohesin function and human disease
N Zhang, LE Coutinho, D Pati - International journal of molecular sciences, 2021 - mdpi.com
Precocious dissociation of sisters 5 (PDS5) is an associate protein of cohesin that is
conserved from yeast to humans. It acts as a regulator of the cohesin complex and plays …
conserved from yeast to humans. It acts as a regulator of the cohesin complex and plays …