Causes of mutation rate variability in plant genomes

D Quiroz, M Lensink, DJ Kliebenstein… - Annual Review of …, 2023 - annualreviews.org
Mutation is the source of all heritable diversity, the essential material of evolution and
breeding. While mutation rates are often regarded as constant, variability in mutation rates …

[HTML][HTML] A fork in the road: Where homologous recombination and stalled replication fork protection part ways

S Tye, GE Ronson, JR Morris - Seminars in Cell & Developmental Biology, 2021 - Elsevier
In response to replication hindrances, DNA replication forks frequently stall and are
remodelled into a four-way junction. In such a structure the annealed nascent strand is …

FIGNL1-FIRRM is essential for meiotic recombination and prevents DNA damage-independent RAD51 and DMC1 loading

A Zainu, P Dupaigne, S Bouchouika, J Cau… - Nature …, 2024 - nature.com
During meiosis, nucleoprotein filaments of the strand exchange proteins RAD51 and DMC1
are crucial for repairing SPO11-generated DNA double-strand breaks (DSBs) by …

Different NIPBL requirements of cohesin-STAG1 and cohesin-STAG2

D Alonso-Gil, A Cuadrado, D Giménez-Llorente… - Nature …, 2023 - nature.com
Cohesin organizes the genome through the formation of chromatin loops. NIPBL activates
cohesin's ATPase and is essential for loop extrusion, but its requirement for cohesin loading …

DNA replication and replication stress response in the context of nuclear architecture

D González-Acosta, M Lopes - Chromosoma, 2024 - Springer
The DNA replication process needs to be coordinated with other DNA metabolism
transactions and must eventually extend to the full genome, regardless of chromatin status …

Specialized functions of cohesins STAG1 and STAG2 in 3D genome architecture

A Cuadrado, A Losada - Current opinion in genetics & development, 2020 - Elsevier
Cohesin is a complex conserved in evolution that entraps DNA. Originally identified for its
role in sister chromatid cohesion, it is currently considered a key player in 3D genome …

A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination

SM Ambjørn, JP Duxin, EPT Hertz, I Nasa… - Nature …, 2021 - nature.com
Mutations in the tumour suppressor gene BRCA2 are associated with predisposition to
breast and ovarian cancers. BRCA2 has a central role in maintaining genome integrity by …

Cohesin mutations in cancer: emerging therapeutic targets

J Antony, CV Chin, JA Horsfield - International journal of molecular …, 2021 - mdpi.com
The cohesin complex is crucial for mediating sister chromatid cohesion and for hierarchal
three-dimensional organization of the genome. Mutations in cohesin genes are present in a …

The dynamic role of cohesin in maintaining human genome architecture

A Agarwal, S Korsak, A Choudhury, D Plewczynski - BioEssays, 2023 - Wiley Online Library
Recent advances in genomic and imaging techniques have revealed the complex manner of
organizing billions of base pairs of DNA necessary for maintaining their functionality and …

PDS5A and PDS5B in cohesin function and human disease

N Zhang, LE Coutinho, D Pati - International journal of molecular sciences, 2021 - mdpi.com
Precocious dissociation of sisters 5 (PDS5) is an associate protein of cohesin that is
conserved from yeast to humans. It acts as a regulator of the cohesin complex and plays …