Digital twins and automation of care in the intensive care unit
Healthcare is under increasing demand pressure as societies age and expectations rise,
multiplied by increasing incidence of chronic diseases and decreasing available funding …
multiplied by increasing incidence of chronic diseases and decreasing available funding …
Virtual patients for mechanical ventilation in the intensive care unit
Background Mechanical ventilation (MV) is a core intensive care unit (ICU) therapy.
Significant inter-and intra-patient variability in lung mechanics and condition makes …
Significant inter-and intra-patient variability in lung mechanics and condition makes …
Over-distension prediction via hysteresis loop analysis and patient-specific basis functions in a virtual patient model
Background and objective Recruitment maneuvers (RMs) with subsequent positive-end-
expiratory-pressure (PEEP) have proven effective in recruiting lung volume and preventing …
expiratory-pressure (PEEP) have proven effective in recruiting lung volume and preventing …
Model-based estimation of negative inspiratory driving pressure in patients receiving invasive NAVA mechanical ventilation
Background Optimisation of mechanical ventilation (MV) and weaning requires insight into
underlying patient breathing effort. Current identifiable models effectively describe lung …
underlying patient breathing effort. Current identifiable models effectively describe lung …
Network data acquisition and monitoring system for intensive care mechanical ventilation treatment
The rise of model-based and machine learning methods have created increasingly realistic
opportunities to implement personalized, patient-specific mechanical ventilation (MV) in the …
opportunities to implement personalized, patient-specific mechanical ventilation (MV) in the …
Digital twins in critical care: what, when, how, where, why?
Healthcare and intensive care unit (ICU) medicine in particular, are facing a devastating
tsunami of rising demand multiplied by increasing chronic disease and aging demographics …
tsunami of rising demand multiplied by increasing chronic disease and aging demographics …
Modeling mechanical ventilation in silico—potential and pitfalls
Computer simulation offers a fresh approach to traditional medical research that is
particularly well suited to investigating issues related to mechanical ventilation. Patients …
particularly well suited to investigating issues related to mechanical ventilation. Patients …
Prediction of lung mechanics throughout recruitment maneuvers in pressure-controlled ventilation
Mechanical ventilation (MV) is a core therapy in the intensive care unit (ICU). Some patients
rely on MV to support breathing. However, it is a difficult therapy to optimise, where inter-and …
rely on MV to support breathing. However, it is a difficult therapy to optimise, where inter-and …
Prediction and estimation of pulmonary response and elastance evolution for volume-controlled and pressure-controlled ventilation
Mechanical ventilation (MV) is a core treatment for patients suffering from respiratory
disease and failure. However, MV settings are not standardized due to significant inter-and …
disease and failure. However, MV settings are not standardized due to significant inter-and …
Virtual patient framework for the testing of mechanical ventilation airway pressure and flow settings protocol
Abstract Background and Objective Model-based and personalised decision support
systems are emerging to guide mechanical ventilation (MV) treatment for respiratory failure …
systems are emerging to guide mechanical ventilation (MV) treatment for respiratory failure …