Surfactant protein D in respiratory and non-respiratory diseases
GL Sorensen - Frontiers in medicine, 2018 - frontiersin.org
Surfactant protein D (SP-D) is a multimeric collectin that is involved in innate immune
defense and expressed in pulmonary, as well as non-pulmonary, epithelia. SP-D exerts …
defense and expressed in pulmonary, as well as non-pulmonary, epithelia. SP-D exerts …
Phenotyping before starting treatment in COPD?
N Siafakas, A Corlateanu, E Fouka - COPD: Journal of Chronic …, 2017 - Taylor & Francis
ABSTRACT Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous and
complex disease with great morbidity and mortality. Despite the new developments in the …
complex disease with great morbidity and mortality. Despite the new developments in the …
Age-related collagen turnover of the interstitial matrix and basement membrane: Implications of age-and sex-dependent remodeling of the extracellular matrix
SN Kehlet, N Willumsen, G Armbrecht, R Dietzel… - PloS one, 2018 - journals.plos.org
The extracellular matrix (ECM) plays a vital role in maintaining normal tissue function.
Collagens are major components of the ECM and there is a tight equilibrium between …
Collagens are major components of the ECM and there is a tight equilibrium between …
Biomarkers of extracellular matrix turnover are associated with emphysema and eosinophilic-bronchitis in COPD
Background Chronic obstructive pulmonary disease (COPD) is characterized by airflow
obstruction and loss of lung tissue mainly consisting of extracellular matrix (ECM). Three of …
obstruction and loss of lung tissue mainly consisting of extracellular matrix (ECM). Three of …
Systemic biomarkers of collagen and elastin turnover are associated with clinically relevant outcomes in COPD
Background Extracellular matrix (ECM) remodeling of the lung tissue releases protein
fragments into the blood, where they may be detected as serologic surrogate markers of …
fragments into the blood, where they may be detected as serologic surrogate markers of …
High levels of biomarkers of collagen remodeling are associated with increased mortality in COPD–results from the ECLIPSE study
Background There is a need to identify individuals with COPD at risk for disease progression
and mortality. Lung tissue remodeling is associated with the release of extracellular matrix …
and mortality. Lung tissue remodeling is associated with the release of extracellular matrix …
Accelerated extracellular matrix turnover during exacerbations of COPD
Background Exacerbations of chronic obstructive pulmonary disease (COPD) contribute
significantly to disease progression. However, the effect on tissue structure and turnover is …
significantly to disease progression. However, the effect on tissue structure and turnover is …
Asthma–COPD overlap syndrome in the US: a prospective population-based analysis of patient-reported outcomes and health care utilization
Background Prior work suggests that asthma–COPD overlap syndrome (ACOS) has a
greater health burden than asthma alone or COPD alone. In the current study, we have …
greater health burden than asthma alone or COPD alone. In the current study, we have …
Lung tissue destruction by proteinase 3 and cathepsin G mediated elastin degradation is elevated in chronic obstructive pulmonary disease
NS Gudmann, T Manon-Jensen, JMB Sand… - Biochemical and …, 2018 - Elsevier
Chronic obstructive pulmonary disease (COPD) is characterized by high levels of protease
activity leading to degradation of elastin followed by loss of elasticity of the lung and the …
activity leading to degradation of elastin followed by loss of elasticity of the lung and the …
Characterization of serological neo-epitope biomarkers reflecting collagen remodeling in clinically stable chronic obstructive pulmonary disease
JMB Sand, G Martinez, AK Midjord, MA Karsdal… - Clinical …, 2016 - Elsevier
Objectives Chronic obstructive pulmonary disease (COPD) is characterized by chronic
inflammation that leads to excessive remodeling of the lung extracellular matrix (ECM) …
inflammation that leads to excessive remodeling of the lung extracellular matrix (ECM) …