Executive summary The Stanford–Lancet Commission on the North American Opioid Crisis
was formed in response to soaring opioid-related morbidity and mortality in the USA and …

Background Excessive opioid prescribing after surgery has contributed to the current opioid
crisis; however, the value of prescribing opioids at surgical discharge remains uncertain. We …

The 2018 Lancet Low Back Pain Series, comprising 3 papers written by 31 authors from
disparate disciplines and 12 different countries, raised unprecedented awareness of the …

Background Previous studies have reported an extremely unbalanced global access to
opioid analgesics. We aimed to determine contemporary trends and patterns of opioid …

Background The US opioid epidemic has led to similar concerns about prescribed opioids in
the UK. In new users, initiation of or escalation to more potent and high dose opioids may …

Background There is considerable public interest in whether Europe is facing an opioid
crisis comparable to the one in the United States and the contribution of opioid prescriptions …

Public Health England exists to protect and improve the nation's health and wellbeing, and
reduce health inequalities. We do this through world-leading science, research, knowledge …

Importance Although tramadol is increasingly used to manage chronic noncancer pain, few
safety studies have compared it with other opioids. Objective To assess the associations of …

In the US, an opioid overdose crisis has emerged, attributable to over-prescription of opioid
analgesics, driven by aggressive marketing by pharmaceutical companies, followed by …

Background Antidepressants, opioids for non-cancer pain, gabapentinoids (gabapentin and
pregabalin), benzodiazepines, and Z-drugs (zopiclone, zaleplon, and zolpidem) are …