This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

Over the past decade, whole genome sequencing and other'omics' technologies have
defined pathogenic driver mutations to which tumor cells are addicted. Such addictions …

Mathematical modeling of biological processes provides deep insights into complex cellular
systems. While quantitative and continuous models such as differential equations have been …

During the last 100 years, cell signaling has evolved into a common mechanism for most
physiological processes across systems. Although the majority of cell signaling principles …

It remains unclear whether causal, rather than merely correlational, relationships in
molecular networks can be inferred in complex biological settings. Here we describe the …

Recent studies across multiple tumour types are starting to reveal a recurrent regulatory
architecture in which genomic alterations cluster upstream of functional master regulator …

Identifying control strategies for biological networks is paramount for practical applications
that involve reprogramming a cell's fate, such as disease therapeutics and stem cell …

Background Cells process signals using complex and dynamic networks. Studying how this
is performed in a context and cell type specific way is essential to understand signaling both …

Traditionally, scientific research has focused on studying individual events, such as single
mutations, gene function, or the effect that mutating one protein has on a biological …

Mitogen-activated protein kinase (MAPK) cascades control cell fate decisions, such as
proliferation, differentiation, and apoptosis by integrating and processing intra-and …