Alkenes and their derivatives are featured widely in a variety of natural products,
pharmaceuticals, and advanced materials. Significant efforts have been made toward the …

Conspectus The use of quaternary stereocenters during lead candidate optimization
continues to grow because of improved physiochemical and pharmacokinetic profiles of …

An electrochemically driven nickel-catalyzed enantioselective reductive cross-coupling of
aryl aziridines with alkenyl bromides has been developed, affording enantioenriched β-aryl …

The activation of carbon–fluorine (C− F) bonds is an important topic in synthetic organic
chemistry. Metal‐mediated and‐catalyzed elimination of β‐or α‐fluorine proceeds under …

Organofluorine compounds have attracted extensive attention in various industrial fields due
to their unique chemical and physical properties. Despite increasing demand in a wide …

To increase the reliability and success rate of drug discovery, efforts have been made to
increase the C (sp 3) fraction and avoid flat molecules. sp 3-Rich enantiopure amines are …

Transformation of sterically hindered tertiary alkyl electrophiles under nickel-catalyzed
conditions to forge C (sp3)–C bonds and simultaneously create challenging all-carbon …

Abstract Enantioselective C (sp 3)–C (sp 3) coupling substantially impacts organic synthesis
but remains challenging. Cobalt has played an important role in the development of …

Developing efficient and selective strategies to approach complex architectures containing
(multi) stereogenic centers has been a long-standing synthetic challenge in both academia …

Much progress has been made in the development of methods to both create compounds
that contain C− F bonds and to functionalize C− F bonds. As such, C− F bonds are becoming …