Programmed cell death has crucial roles in the physiological maturation of an organism, the
maintenance of metabolism, and disease progression. Pyroptosis, a form of programmed …

Transcription factors play multifaceted roles in embryonic development and diseases. PAX1,
a paired-box transcription factor, has been elucidated to play key roles in multiple tissues …

Background Congenital scoliosis is a common type of vertebral malformation. Genetic
susceptibility has been implicated in congenital scoliosis. Methods We evaluated 161 Han …

Idiopathic scoliosis (IS) is a common paediatric musculoskeletal disease that displays a
strong female bias. By performing a genome-wide association study (GWAS) of 3,102 …

Congenital vertebral malformations (CVM) pose a significant health problem because they
can be associated with spinal deformities, such as congenital scoliosis and kyphosis, in …

Human vertebral malformations (VMs) have an estimated incidence of 1/2000 and are
associated with significant health problems including congenital scoliosis (CS) and recurrent …

Introduction In preorthodontic children with Class II malocclusion and horizontal maxillary
overjet, cervical column morphology was examined and related to craniofacial morphology …

Deoxynivalenol (DON) is a toxic fungal secondary metabolite produced by molds of the
Fusarium genus, and it is known to cause a spectrum of diseases both in humans and …

Vertebral malformations contribute substantially to the pathophysiology of kyphosis and
scoliosis, common health problems associated with back and neck pain, disability, cosmetic …

Congenital scoliosis (CS) occurs as a result of vertebral malformations and has an incidence
of 0.5–1/1,000 births. Recently, TBX6 on chromosome 16p11. 2 was reported as a disease …