Cardiomyocytes are large (∼ 40,000 µm3), rod-shaped muscle cells that provide the
working force behind each heartbeat. These highly structured cells are packed with dense …

Neurite outgrowth underlies the wiring of the nervous system during development and
regeneration. Despite a significant body of research, the underlying cytoskeletal mechanics …

Neurons are akin to modern cities in that both are dependent on robust transport
mechanisms. Like the best mass transit systems, trafficking in neurons must be tailored to …

Axons are cable-like neuronal processes wiring the nervous system. They contain parallel
bundles of microtubules as structural backbones, surrounded by regularly spaced actin rings …

Stretch-growth has been defined as a process that extends axons via the application of
mechanical forces. In the present article, we used a protocol based on magnetic …

Axons are the slender, cable-like, up to meter-long projections of neurons that electrically
wire our brains and bodies. In spite of their challenging morphology, they usually need to be …

Microtubules (MTs) play roles in regulating the mechanical structure and dynamics of cells.
While MTs appear to be highly ordered structures, recent data suggest some randomness in …

The formation and maintenance of microtubules requires their polymerisation, but little is
known about how this polymerisation is regulated in cells. Focussing on the essential …

In neurons, microtubule networks alternate between single filaments and bundled arrays
under the influence of effectors controlling their dynamics and organization. Tau is a …

Axons are processes of neurons, up to a metre long, that form the essential biological cables
wiring nervous systems. They must survive, often far away from their cell bodies and up to a …