The 2022 WHO classification of tumors of the pituitary gland: An update on aggressive and metastatic pituitary neuroendocrine tumors

O Casar‐Borota, P Burman, MB Lopes - Brain Pathology, 2024 - Wiley Online Library
The vast majority of pituitary neuroendocrine tumors (PitNETs) are benign and slow growing
with a low relapse rate over many years after surgical resection. However, about 40% are …

Genomics, Transcriptomics, and Epigenetics of Sporadic Pituitary Tumors

D Marrero-Rodríguez, S Vela-Patiño… - Archives of Medical …, 2023 - Elsevier
Pituitary tumors (PT) are highly heterogeneous neoplasms, comprising functioning and
nonfunctioning lesions. Functioning PT include prolactinomas, causing amenorrhea …

Single-cell transcriptomic analysis reveals tumor cell heterogeneity and immune microenvironment features of pituitary neuroendocrine tumors

N Yan, W Xie, D Wang, Q Fang, J Guo, Y Chen, X Li… - Genome Medicine, 2024 - Springer
Abstract Background Pituitary neuroendocrine tumors (PitNETs) are one of the most
common types of intracranial tumors. Currently, the cellular characteristics of normal pituitary …

FTO-mediated DSP m6A demethylation promotes an aggressive subtype of growth hormone-secreting pituitary neuroendocrine tumors

Y Zou, X Bao, D Li, Z Ye, R Xiang, Y Yang, Z Zhu… - Molecular Cancer, 2024 - Springer
Background Growth hormone-secreting pituitary neuroendocrine tumors can be
pathologically classified into densely granulated (DGGH) and sparsely granulated types …

Erythropoietin-producing hepatocellular receptor B6 is highly expressed in non-functioning pituitary neuroendocrine tumors and its expression correlates with tumor …

H Rubinfeld, ZR Cohen, U Bendavid… - Molecular biology …, 2024 - Springer
Background Erythropoietin-producing hepatocellular (EPH) receptors are the largest known
family of receptor tyrosine kinases characterized in humans. These proteins are involved in …

Single-cell transcriptomics reveal distinct immune-infiltrating phenotypes and macrophage–tumor interaction axes among different lineages of pituitary …

S Lin, Y Dai, C Han, T Han, L Zhao, R Wu, J Liu… - Genome Medicine, 2024 - Springer
Abstract Background Pituitary neuroendocrine tumors (PitNETs) are common gland
neoplasms demonstrating distinctive transcription factors. Although the role of immune cells …

The molecular biology of sporadic acromegaly

D Marrero-Rodríguez, A Moscona-Nissan… - Best Practice & …, 2024 - Elsevier
GH-secreting tumors represent 15% to 20% of all pituitary neuroendocrine tiumors
(pitNETs), of which 95% occur in a sporadic context, without an identifiable inherited cause …

Longitudinal multiomics analysis of aggressive pituitary neuroendocrine tumors: comparing primary and recurrent tumors from the same patient, reveals genomic …

K Taniguchi-Ponciano, S Hinojosa-Alvarez… - Acta Neuropathologica …, 2024 - Springer
Pituitary neuroendocrine tumors (PitNET) represent the vast majority of sellar masses. Some
behave aggressively, growing rapidly and invading surrounding tissues, with high rates of …

PCSK1N as a tumor size marker and an ER stress response protein in corticotroph pituitary adenomas

M Abusdal, KR Normann, TA Nyman… - The Journal of …, 2024 - academic.oup.com
Context Silent corticotroph adenoma (SCA) exhibits more tumor aggressiveness features
than functioning adenomas (FCAs). Objective We aimed to investigate proprotein …

Single-cell transcriptomics link gene expression signatures to clinicopathological features of gonadotroph and lactotroph PitNET

TE Potthoff, C Walter, D Jeising, D Münter… - Journal of translational …, 2024 - Springer
Abstract Background Pituitary neuroendocrine tumors (PitNET) are among the most common
intracranial tumors. Despite a frequent benign course, aggressive behavior can occur …