The potential role of N7-methylguanosine (m7G) in cancer

Y Luo, Y Yao, P Wu, X Zi, N Sun, J He - Journal of hematology & oncology, 2022 - Springer
Abstract N 7-methylguanosine (m7G), one of the most prevalent RNA modifications, has
recently attracted significant attention. The m7G modification actively participates in …

Ribosome biogenesis factors—from names to functions

K Dörner, C Ruggeri, I Zemp, U Kutay - The EMBO journal, 2023 - embopress.org
The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …

New insights into the interplay between long non‐coding RNAs and RNA‐binding proteins in cancer

ZT Yao, YM Yang, MM Sun, Y He, L Liao… - Cancer …, 2022 - Wiley Online Library
With the development of proteomics and epigenetics, a large number of RNA‐binding
proteins (RBPs) have been discovered in recent years, and the interaction between long …

[HTML][HTML] Acetylation of cytidine in mRNA promotes translation efficiency

D Arango, D Sturgill, N Alhusaini, AA Dillman, TJ Sweet… - Cell, 2018 - cell.com
Generation of the" epitranscriptome" through post-transcriptional ribonucleoside
modification embeds a layer of regulatory complexity into RNA structure and function. Here …

[HTML][HTML] A large-scale binding and functional map of human RNA-binding proteins

EL Van Nostrand, P Freese, GA Pratt, X Wang, X Wei… - Nature, 2020 - nature.com
Many proteins regulate the expression of genes by binding to specific regions encoded in
the genome 1. Here we introduce a new data set of RNA elements in the human genome …

Ribosome biogenesis in cancer: new players and therapeutic avenues

J Pelletier, G Thomas, S Volarević - Nature Reviews Cancer, 2018 - nature.com
The ribosome is a complex molecular machine composed of numerous distinct proteins and
nucleic acids and is responsible for protein synthesis in every living cell. Ribosome …

Ribosome assembly coming into focus

S Klinge, JL Woolford Jr - Nature reviews Molecular cell biology, 2019 - nature.com
In the past 25 years, genetic and biochemical analyses of ribosome assembly in yeast have
identified most of the factors that participate in this complex pathway and have generated …

Noncoding mutations cause super-enhancer retargeting resulting in protein synthesis dysregulation during B cell lymphoma progression

RJ Leeman-Neill, D Song, J Bizarro, L Wacheul… - Nature …, 2023 - nature.com
Whole-genome sequencing of longitudinal tumor pairs representing transformation of
follicular lymphoma to high-grade B cell lymphoma with MYC and BCL2 rearrangements …

lncRNA SLERT controls phase separation of FC/DFCs to facilitate Pol I transcription

M Wu, G Xu, C Han, PF Luan, YH Xing, F Nan, LZ Yang… - Science, 2021 - science.org
RNA polymerase I (Pol I) transcription takes place at the border of the fibrillar center (FC)
and the dense fibrillar component (DFC) in the nucleolus. Here, we report that individual …

Tuning the ribosome: the influence of rRNA modification on eukaryotic ribosome biogenesis and function

KE Sloan, AS Warda, S Sharma, KD Entian… - RNA biology, 2017 - Taylor & Francis
ABSTRACT rRNAs are extensively modified during their transcription and subsequent
maturation in the nucleolus, nucleus and cytoplasm. RNA modifications, which are installed …