Nerves in cancer
AH Zahalka, PS Frenette - Nature Reviews Cancer, 2020 - nature.com
The contribution of nerves to the pathogenesis of malignancies has emerged as an
important component of the tumour microenvironment. Recent studies have shown that …
important component of the tumour microenvironment. Recent studies have shown that …
DREADDs for neuroscientists
BL Roth - Neuron, 2016 - cell.com
To understand brain function, it is essential that we discover how cellular signaling specifies
normal and pathological brain function. In this regard, chemogenetic technologies represent …
normal and pathological brain function. In this regard, chemogenetic technologies represent …
BDNF and synaptic plasticity, cognitive function, and dysfunction
B Lu, G Nagappan, Y Lu - Neurotrophic factors, 2014 - Springer
Among all neurotrophins, brain-derived neurotrophic factor (BDNF) stands out for its high
level of expression in the brain and its potent effects on synapses. It is now widely accepted …
level of expression in the brain and its potent effects on synapses. It is now widely accepted …
BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases
B Lu, G Nagappan, X Guan, PJ Nathan… - Nature Reviews …, 2013 - nature.com
Increasing evidence suggests that synaptic dysfunction is a key pathophysiological hallmark
in neurodegenerative disorders, including Alzheimer's disease. Understanding the role of …
in neurodegenerative disorders, including Alzheimer's disease. Understanding the role of …
[HTML][HTML] Development and plasticity of the primary visual cortex
JS Espinosa, MP Stryker - Neuron, 2012 - cell.com
Hubel and Wiesel began the modern study of development and plasticity of primary visual
cortex (V1), discovering response properties of cortical neurons that distinguished them from …
cortex (V1), discovering response properties of cortical neurons that distinguished them from …
Fracture repair requires TrkA signaling by skeletal sensory nerves
Z Li, CA Meyers, L Chang, S Lee, Z Li… - The Journal of …, 2019 - Am Soc Clin Investig
Bone is richly innervated by nerve growth factor–responsive (NGF-responsive) tropomyosin
receptor kinase A–expressing (TrKa-expressing) sensory nerve fibers, which are required …
receptor kinase A–expressing (TrKa-expressing) sensory nerve fibers, which are required …
Chemogenetic tools to interrogate brain functions
SM Sternson, BL Roth - Annual review of neuroscience, 2014 - annualreviews.org
Elucidating the roles of neuronal cell types for physiology and behavior is essential for
understanding brain functions. Perturbation of neuron electrical activity can be used to probe …
understanding brain functions. Perturbation of neuron electrical activity can be used to probe …
Direct current stimulation promotes BDNF-dependent synaptic plasticity: potential implications for motor learning
Despite its increasing use in experimental and clinical settings, the cellular and molecular
mechanisms underlying transcranial direct current stimulation (tDCS) remain unknown …
mechanisms underlying transcranial direct current stimulation (tDCS) remain unknown …
Autocrine BDNF–TrkB signalling within a single dendritic spine
SC Harward, NG Hedrick, CE Hall, P Parra-Bueno… - Nature, 2016 - nature.com
Brain-derived neurotrophic factor (BDNF) and its receptor TrkB are crucial for many forms of
neuronal plasticity,,,,,, including structural long-term potentiation (sLTP),, which is a correlate …
neuronal plasticity,,,,,, including structural long-term potentiation (sLTP),, which is a correlate …
Postsynaptic BDNF‐TrkB signaling in synapse maturation, plasticity, and disease
A Yoshii, M Constantine‐Paton - Developmental neurobiology, 2010 - Wiley Online Library
Brain‐derived neurotrophic factor (BDNF) is a prototypic neurotrophin that regulates diverse
developmental events from the selection of neural progenitors to the terminal dendritic …
developmental events from the selection of neural progenitors to the terminal dendritic …