Degradation of mitochondria via a selective form of autophagy, named mitophagy, is a
fundamental mechanism conserved from yeast to humans that regulates mitochondrial …

The integrity of mitochondrial function is fundamental to cell life. It follows that disturbances
of mitochondrial function will lead to disruption of cell function, expressed as disease or …

Myogenesis is a crucial process governing skeletal muscle development and homeostasis.
Differentiation of primitive myoblasts into mature myotubes requires a metabolic switch to …

Mitochondrial biogenesis and mitochondrial DNA (mtDNA) maintenance depend on
coordinated expression of genes in the nucleus and mitochondria. A variety of intracellular …

The non-invasive high-resolution spatial mapping of cell metabolism within tissues could
provide substantial advancements in assessing the efficacy of stem cell therapy and …

We recently found that long-term exposure to nitric oxide (NO) triggers mitochondrial
biogenesis in mammalian cells and tissues by activation of guanylate cyclase and …

The estrogen-related receptors (ERRs) comprise a small group of orphan nuclear receptor
transcription factors. The ERRα and ERRγ isoforms play a central role in the regulation of …

The purpose of this study was to investigate the changes in the gene expression of
Mitofusion (Mfn) 1 and 2 and Fission 1 (Fis1) and mitochondrial energy metabolism in …

The intermuscular adipose tissue (IMAT) is a depot of adipocytes located between muscle
bundles. Several investigations have recently been carried out to define the phenotype, the …

We have generated an animal model for mitochondrial myopathy by disrupting the gene for
mitochondrial transcription factor A (Tfam) in skeletal muscle of the mouse. The knockout …