Simple Summary Pancreatic neuroendocrine tumors (pNETs) are rare, indolent cancers
whose causation is only partly understood. An increasing number of studies have uncovered …

Somatostatin (SST) is a small peptide that exerts inhibitory effects on a wide range of
neuroendocrine cells. Due to the fact that somatostatin regulates cell growth and hormone …

Tumour heterogeneity is a common phenomenon in neuroendocrine neoplasms (NENs)
and a significant cause of treatment failure and disease progression. Genetic and epigenetic …

Patients with advanced-stage gastroenteropancreatic neuroendocrine tumors (GEP-NETs)
have a poor overall prognosis despite chemotherapy and radiotherapy (eg, peptide receptor …

Pancreatic neuroendocrine neoplasms (pNENs) are rare cancers with broad challenges for
their management. The main clinical obstacles are the high rate of patients diagnosed at …

Purpose Recent studies claim that immune checkpoint inhibitors are effective in defective
mismatch repair (dMMR) cancers. This raises the question of whether similar therapies are …

Introduction: Treatment response to the standard therapy is low for metastatic pancreatic
neuroendocrine tumors (PanNETs) mainly due to the tumor heterogeneity. We investigated …

Data are a collection of facts and numerical information that, after proper analysis, allow us
to gather a picture of reality and address our research questions. Furthermore, data are …