Development of highly effective, broad-spectrum antiviral agents is the major objective
shared by the fields of virology and pharmaceutics. Antiviral drug development has focused …

Mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of cellular
proliferation and survival which controls cellular response to different stresses, including …

Stress granules (SG) are translationally silent sites of RNA triage induced by environmental
stresses including viral infection. Here we show that HIV-1 Gag blocks SG assembly …

HIV has posed a significant challenge due to the ability of the virus to both impair and evade
the host's immune system. One of the most important mechanisms it has employed to do so …

Yellow fever virus (YFV) replication is highly dependent on host cell factors. YFV NS4B is
reported to be involved in viral replication and immune evasion. Here interactions between …

HIV-1 infects T cells, but the most frequent AIDS-related lymphomas are of B-cell origin.
Molecular mechanisms of HIV-1-induced oncogenic transformation of B cells remain largely …

Prior studies have found that HIV, through the Vpr protein, promotes genome reduplication
(polyploidy) in infection-surviving epithelial cells within renal tissue. However, the temporal …

Oxidative stress has been implicated to contribute to HIV-induced kidney cell injury;
however, the role of p53, a modulator of oxidative stress, has not been evaluated in the …

MicroRNAs (miRNAs) play a critical role in multiple biological and metabolic processes.
Recent studies suggested that miRNAs are critical in the maintenance of glomerular …

Mammalian target of rapamycin (mTOR) has been reported to contribute to the development
of HIV-associated nephropathy (HIVAN). We hypothesized that HIV may be activating renal …